Optical coherence tomography: Technology and applications for neuroimaging
Optical coherence tomography: Technology and applications for neuroimaging
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DOI：
10.1111/1469-8986.00055
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发表时间：
2003-07-01
期刊：
影响因子：
3.7
通讯作者：
Boppart, SA
中科院分区：
文献类型：
--
作者：
Boppart, SA
光学相干断层扫描 (OCT) 是一种新兴的成像技术，可应用于生物学、医学和材料研究。有吸引力的功能包括高细胞级分辨率、实时采集率以及紧凑型无创仪器中的光谱特征提取。 OCT 可以对组织进行“光学活检”，产生接近组织学分辨率的图像，而无需切除和组织学处理组织样本来进行表征和诊断。本文将回顾目前 OCT 的一些技术发展。为了说明该技术在神经成像方面的潜力，将介绍神经发育成像、神经视网膜、中枢神经系统肿瘤和周围神经显微外科修复的应用。这项技术为解决神经影像学领域当前的许多挑战提供了一种潜在的研究工具。
Optical coherence tomography (OCT) is an emerging imaging technology with applications in biology, medicine, and materials investigations. Attractive features include high cellular-level resolution, real-time acquisition rates, and spectroscopic feature extraction in a compact noninvasive instrument. OCT can perform "optical biopsies" of tissue, producing images approaching the resolution of histology without having to resect and histologically process tissue specimens for characterization and diagnosis. This article will review several of the current technological developments in OCT. To illustrate the potential of this technology for neuroimaging, applications for imaging neural development, the neural retina, tumors of the central nervous system, and the microsurgical repair of peripheral nerves will be presented. This technology offers a potential investigative tool for addressing many of the present challenges in neuroimaging.