CHARACTERIZATION OF A HUMAN Y-CHROMOSOME REPEATED SEQUENCE AND RELATED SEQUENCES IN HIGHER PRIMATES
CHARACTERIZATION OF A HUMAN Y-CHROMOSOME REPEATED SEQUENCE AND RELATED SEQUENCES IN HIGHER PRIMATES
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DOI：
10.1007/bf00333470
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发表时间：
1982-01-01
期刊：
影响因子：
1.6
通讯作者：
GOSDEN, JR
中科院分区：
文献类型：
--
作者：
COOKE, HJ;SCHMIDTKE, J;GOSDEN, JR
人类Y染色体携带2000个串联重复序列，长2.47 kb，约占该染色体DNA的20%。这些序列位于Y染色体长臂的尖端。相关序列存在于女性DNA中，具有相关但可区分的限制性模式。这些常染色体序列以串联阵列分布在许多常染色体上。相关序列也存在于大猩猩和黑猩猩中。在大猩猩中，它们类似于人类的限制序列，但在Y染色体上没有发现，而在黑猩猩中，相关序列表现为分散重复。人类男性不同组织中该序列甲基化水平的变化可以在精子和胎盘DNA中发现最低水平。
The human Y chromosome carries 2000 copies of a tandemly repeated sequence, 2.47 kb [kilobase] long, which constitutes about 20% of the DNA of this chromosome. These sequences are localized on the tip of the long arm of the Y chromosome. Related sequences are present in DNA of females with a related but distinguishable restriction pattern. These autosomal sequences are distributed in tandem arrays on a number of autosomes. Related sequences are also present in gorilla and chimpanzee. In gorilla they resemble the human sequences in their restriction map but are not found on the Y chromosome whereas in chimpanzee the related sequences behave as a dispersed repeat. Changes in the level of methylation of this sequence in different tissues of human males can be detected with the lowest levels found in sperm and placental DNA.