Synthesis of the First Ferrocenyl Derivatives of Curcuminoids
Synthesis of the First Ferrocenyl Derivatives of Curcuminoids
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DOI：
10.1021/om900003g
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发表时间：
2009-03-23
期刊：
影响因子：
2.8
通讯作者：
Jaouen, Gerard
中科院分区：
文献类型：
--
作者：
Arezki, Anusch;Brule, Emilie;Jaouen, Gerard
采用两种策略研究了二茂铁基部分共价结合的姜黄素类化合物的合成：在3，4-二甲基姜黄素的Knovenagel缩合反应中引入二茂铁基单元，以及3，5-二甲基姜黄素和姜黄素的烯醇化产物在二茂铁基丙酮上进行1，4-加成反应。
The synthesis of curcuminoids covalently bound to a ferrocenyl moiety was investigated using two strategies: a ferrocenyl unit was incorporated during the synthesis of 3,4-dimethylcurcumin using a Knoevenagel condensation, and the enolates of 3,5-dimethylcurcumin and curcumin, previously protected, underwent a 1,4-addition on ferrocenyl propynone.