Ancient mitochondrial genome reveals trace of prehistoric migration in the east Pamir by pastoralists
Ancient mitochondrial genome reveals trace of prehistoric migration in the east Pamir by pastoralists
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DOI：
10.1038/jhg.2015.128
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发表时间：
2016-02-01
影响因子：
3.5
通讯作者：
Cui, Yinqiu
中科院分区：
文献类型：
--
作者：
Ning, Chao;Gao, Shizhu;Cui, Yinqiu
为了揭示塔什库尔干人的种群历史，确定单倍群U 5a的系统发育关系，对新疆塔什库尔干地区一个700岁个体的线粒体全基因组进行了目标富集和测序。这个古老的样本被分配到单倍群U 5a 2a 1的一个亚支，该单倍群由16114 A和13928 C处的两个罕见且稳定的颠换定义。系统发育分析表明，U 5a 2a的分布模式，这是在伏尔加-乌拉尔地区的起源，并表现出明显的向东的地理扩张，与畜牧文化也进入欧亚草原。塔什库尔干人的单倍群U 5a 2a揭示了牧民在东帕米尔高原的史前迁徙。研究结果表明，研究古代线粒体基因组是研究东帕米尔高原演化过程和种群历史的有效途径。
The complete mitochondrial genome of one 700-year-old individual found in Tashkurgan, Xinjiang was target enriched and sequenced in order to shed light on the population history of Tashkurgan and determine the phylogenetic relationship of haplogroup U5a. The ancient sample was assigned to a subclade of haplogroup U5a2a1, which is defined by two rare and stable transversions at 16114A and 13928C. Phylogenetic analysis shows a distribution pattern for U5a2a that is indicative of an origin in the Volga-Ural region and exhibits a clear eastward geographical expansion that correlates with the pastoral culture also entering the Eurasian steppe. The haplogroup U5a2a present in the ancient Tashkurgan individual reveals prehistoric migration in the East Pamir by pastoralists. This study shows that studying an ancient mitochondrial genome is a useful approach for studying the evolutionary process and population history of Eastern Pamir.