WOUND-HEALING AFTER EXCIMER LASER KERATOMILEUSIS (PHOTOREFRACTIVE KERATECTOMY) IN MONKEYS
WOUND-HEALING AFTER EXCIMER LASER KERATOMILEUSIS (PHOTOREFRACTIVE KERATECTOMY) IN MONKEYS
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DOI：
10.1001/archopht.1990.01070070051034
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发表时间：
1990-05-01
影响因子：
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通讯作者：
SAVOLDELLI, M
中科院分区：
文献类型：
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作者：
FANTES, FE;HANNA, KD;SAVOLDELLI, M
本文报告用193 nm氟化氩准分子激光器和计算机控制的移动狭缝输送系统对29只恒河猴角膜进行了激光近视角膜磨镶术（屈光性角膜切削术）。直径为4 mm的中心消融区的深度范围为11 μ m（-2屈光度效应）至46 μ m（-8屈光度效应）。术后9个月，通过临床粉光灯显微镜对角膜进行研究，并定期进行光学和透射电子显微镜检查。到6周时，93%的角膜出现轻度至中度上皮下混浊，密度变化相当大。进行性透明化发生，因此，到6至9个月时，13个存活角膜中的12个（92%）完全透明（4个角膜）或微量模糊（8个角膜）。消融后21天上皮增厚，3个月时恢复正常厚度。3周时，上皮下成纤维细胞的密度是正常角膜细胞的3倍，9个月时恢复到接近正常的数量。我们的结论是，前猴角膜表现出轻微的，典型的伤口愈合反应后，准分子激光角膜磨镶术。
Laser myopic keratomileusis (photrefractive keratectomy) was performd on 29 rhesus monkey corneas with an argon fluoride (193-nm) excimer laser and a computer-controlled, moving slit delivery system. The 4-mm-diameter central ablation zone ranged in depth for 11 .mu.m (-2 diopters effect) to 46 .mu.m (-8 diopters effect). Corneas were studied for the 9 months postoperatively by clinical silt-lamp microscopy, and periodically with light and transmission electron microscopy. By 6 weeks, mild to moderate subepithelial haze was apparent in 93% of the corneas, with considerable variability in density. Progressive clearing occurred so that by 6 to 9 months 12 of 13 surviving corneas (92%) were either completely clear (4 corneas) or trace hazy (8 corneas). The epithelium was thickened at 21 days after ablation and returned to normal thickness by 3 months. At 3 weeks, subepithelial fibroblasts were three times the density of normal keratocytes and returned to nearly normal numbers by 9 months. We concluded that the anterior monkey cornea demonstrated a mild, typical wound healing response after excimer laser keratomileusis.