The effects of preconditioning strain on measured tissue properties
The effects of preconditioning strain on measured tissue properties
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DOI：
10.1016/j.jbiomech.2009.03.023
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发表时间：
2009-06-19
影响因子：
2.4
通讯作者：
Bilston, Lynne E.
中科院分区：
文献类型：
--
作者：
Cheng, Shaokoon;Clarke, Elizabeth C.;Bilston, Lynne E.
表征生物软组织的力学特性是一项艰巨的挑战。为了保证试样的结构处于可重复的参考状态，通常在实际试验前进行预处理。然而，预处理的确切机制尚不清楚，需要对这一问题进行更多的研究，以便预处理的方法可以改进以减少实验的可变性。以往的研究表明，预适应应变的选择可能会影响测量的性能。本研究对三组脊髓组织进行单轴试验。两组（1组和2组）以5%的应变进行预处理，分别测试至5%和2%；第三组（3组）以2%的应变进行预处理，测试至2%。在2%应变下，3组的峰值应力为0.0054±0.0035 MPa，显著高于2组（134%,p = 0.015）和1组（p = 0.005）。然而，两种预处理应变的峰值与平衡应力之比和松弛时间相似。本研究提示，在今后的工作中，应报道预处理应变，并采用研究中使用的最高应变进行预处理。这对于本研究和其他研究的测试数据进行有意义的比较是很重要的。2009爱思唯尔有限公司版权所有。
Characterizing the mechanical properties of soft biological tissues presents a formidable challenge. In order to ensure that the structure of the specimens is at a repeatable reference state, preconditioning is commonly performed before the actual test. However, the exact mechanisms of preconditioning remain unclear and more research on this issue needs to be undertaken so that the methods for preconditioning can be refined to reduce experimental variability. Previous studies have suggested that the choice of preconditioning strain may influence the measured properties. In this study, uniaxial tests were performed on three groups of spinal cord tissues. Two groups (Groups 1 and 2) were preconditioned at 5% strain and tested to 5% and 2% each, while the third (Group 3) was preconditioned at 2% strain and tested to 2%. The peak stress measured at 2% strain for group 3 was 0.0054 +/- 0.0035 MPa and this was significantly higher than group 2 (134%; p = 0.015) and group 1 (p = 0.005). However, the ratio of peak to equilibrium stress and the relaxation time were similar for both preconditioning strains. This study suggests that in future work, the preconditioning strain should be reported and the highest strain being used in the study should be used for preconditioning. This is important to allow meaningful comparison of test data within the study and also with other studies. (C) 2009 Elsevier Ltd. All rights reserved.