A comparison of memory for verbal and non-verbal material in schizophrenia.
A comparison of memory for verbal and non-verbal material in schizophrenia.
复制标题
精神分裂症患者言语和非言语材料记忆的比较。
DOI：
10.1016/s0920-9964(01)00241-9
复制
发表时间：
2001
影响因子：
4.5
通讯作者：
Glosser,G
中科院分区：
文献类型：
--
作者：
Tracy,JI;Mattson,R;King,C;Bundick,T;Celenza,MA;Glosser,G
言语记忆障碍已经在精神分裂症中得到了很好的研究，但尚不清楚这些发现是否与学习材料的类型或记忆任务所需的组成过程有关。此外，关于非语言记忆的稀疏数据也开启了精神分裂症患者如何编码这些材料的问题。我们测试了精神分裂症患者的情景记忆表现是否随刺激材料（言语/非言语）的变化而变化，并确定了各种成分记忆过程的完整性。刺激材料不同的记忆测试（单词，加州语言学习测试，CVLT；设计，Biber图形学习测试扩展，BFLT-E）产生相似的记忆成分测量。研究对象为28例诊断为慢性精神分裂症并服用抗精神病药物的住院患者。结果显示，与年龄匹配的对照组相比，语言和非语言记忆的表现都受到了损害。学习和回忆能力受损最严重，记忆储存问题和识别记忆损伤明显。在言语任务中，识别记忆的相对保留表明，除编码过程外，检索过程也受到干扰。在非语言任务中，缺陷似乎更局限于编码。因此，尽管编码等组成部分的操作完整性受到损害，但检索过程显示出材料特异性效应。就言语和非言语记忆功能在大脑中可以侧化的程度而言，这些数据支持了精神分裂症患者左右半球陈述性记忆系统都存在缺陷的可能性。
Verbal memory impairment has been well explored in schizophrenia, but it is unclear whether findings relate to the type of material to be learned or the component process required by the memory task. Also, sparse data on non-verbal memory also open the question of how well schizophrenia patients encode this material. We tested whether episodic memory performance in schizophrenia varies as a function of stimulus material (verbal/non-verbal) and determined the integrity of various component memory processes. Memory tests that differ in stimulus material (words, California Verbal Learning Test, CVLT; designs, Biber Figure Learning Test-Extended, BFLT-E) yet produce similar memory component measures were used. Subjects were 28 neuroleptic-medicated inpatients with a diagnosis of chronic schizophrenia. Results showed that both verbal and non-verbal memory performance was impaired relative to age-matched controls. Learning and recall measures were most severely impaired, with memory storage problems and impairment in recognition memory evident. On the verbal task, the relative sparing of recognition memory suggested retrieval processes, in addition to encoding processes, were disrupted. On the non-verbal task, the deficits appeared more limited to encoding. Therefore, while the operational integrity of components such as encoding were compromised regardless of material, retrieval processes showed material-specific effects. To the degree verbal and non-verbal memory functions can be lateralized in the brain, these data support the possibility of deficits in both right and left hemisphere declarative memory systems in schizophrenia.