Comparison of different definitions of pediatric metabolic syndrome: Relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers
Comparison of different definitions of pediatric metabolic syndrome: Relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers
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DOI：
10.1016/j.jpeds.2007.07.053
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发表时间：
2008-02-01
影响因子：
5.1
通讯作者：
Arslanian, Silva
中科院分区：
文献类型：
--
作者：
Lee, Sojung;Bacha, Fida;Arslanian, Silva
目的研究文献中不同儿科定义的代谢综合征患病率及其与腹部脂肪组织（AT）、体内胰岛素抵抗、儿童和青少年炎症生物标志物的关系，以及空腹胰岛素和脂联素作为代谢综合征预测因子的效用。研究设计对122名8至19岁的非裔美国人和129名白种人进行了横断面测量。胰岛素敏感性（IS）通过3小时高胰岛素-血糖钳夹测定。测量血压、空腹血脂、脂联素、白细胞介素(IL)-6、黏附分子（细胞间黏附分子[ICAM]-1、血管细胞黏附分子[VCAM]-1、e -选择素）、腹部AT。结果无论使用何种代谢综合征标准，非裔美国人和白种人中超重的代谢综合征患病率（24%相似于51%）高于非超重的年轻人（1%相似于3%）
Objectives To examine the prevalence of the metabolic syndrome using different pediatric definitions reported in the literature and its relationship to abdominal adipose tissue (AT), in vivo insulin resistance, and inflammatory biomarkers in children and adolescents, as well as the utility of fasting insulin and adiponectin as predictors of the metabolic syndrome.Study design Cross-sectional measurements were obtained from 122 African Americans and 129 Caucasians age 8 to 19 years. Insulin sensitivity (IS) was measured by a 3-h hyperinsulinemic-euglycemic clamp. Blood pressure, fasting lipids, adiponectin, interleukin (IL)-6, adhesion molecules (intercellular adhesion molecule [ICAM]-1, vascular cell adhesion molecule [VCAM]-1, and E-selectin), and abdominal AT were measured.Results Regardless of the metabolic syndrome criteria used, the prevalence of the metabolic syndrome was higher in overweight (24%similar to 51%) compared with non-overweight youths (1%similar to 3%) in both African Americans and Caucasians (P