Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
复制标题
DOI：
10.1161/atvbaha.107.153288
复制
发表时间：
2007-12-01
影响因子：
8.7
通讯作者：
Vita, Joseph A.
中科院分区：
文献类型：
--
作者：
Hamburg, Naomi M.;McMackin, Craig J.;Vita, Joseph A.
目标——久坐的生活方式会增加患心血管疾病和糖尿病的风险。血管功能障碍会导致动脉粥样硬化，并与胰岛素抵抗有关。 方法和结果 - 我们通过葡萄糖耐量试验测量了胰岛素敏感性，并通过超声和静脉闭塞体积描记法测量了 20 名健康受试者（14 名男性，6 名女性）在基线和卧床休息 5 天期间的血管功能。卧床休息导致胰岛素对葡萄糖负荷的反应增加 67%（P
Objectives-Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance.Methods and Results-We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and during 5 days of bed rest. Bed rest led to a 67% increase in the insulin response to glucose loading (P