Abnormally increased and incoherent resting-state activity is shared between patients with schizophrenia and their unaffected siblings
Abnormally increased and incoherent resting-state activity is shared between patients with schizophrenia and their unaffected siblings
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精神分裂症患者及其未受影响的兄弟姐妹之间都存在异常增加且不连贯的静息状态活动
DOI：
10.1016/j.schres.2016.01.022
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发表时间：
2016-03-01
影响因子：
4.5
通讯作者：
Pu, Weidan
中科院分区：
文献类型：
--
作者：
Liu, Chang;Xue, Zhimin;Pu, Weidan
背景：几项精神分裂症的静息状态神经影像学研究表明，精神分裂症患者的大脑活动过度，而另一些人则报告休息时的大脑活动不连贯。到目前为止，还没有直接证据表明过度和不连贯的大脑活动同时存在。此外，尚不清楚精神分裂症患者的未受影响的兄弟姐妹是否也表现出过度和不连贯的大脑活动，这可能使他们容易患上精神分裂症。方法：对27对精神分裂症患者及其未患病兄弟姐妹和27名健康对照进行静息时梯度回波回波平面成像扫描。通过低频波动幅度（ALFF）和区域均匀性（Reho），我们研究了三组局部自发神经元活动的强度和同步。结果：我们观察到自发性神经元活动的幅度增加和同步性（一致性）降低在患者和未受影响的兄弟姐妹中是共同的。在患者和兄弟姐妹中出现这种异常神经模式的关键脑区包括颞中、眶额、枕下和额岛回。结论：精神分裂症患者及其健康兄弟姐妹所共有的神经活动过度和不连贯的异常神经模式可能有助于我们对精神分裂症的神经病理学和遗传易感性的理解。(C) 2016 Elsevier b.v.版权所有
Background: Several resting-state neuroimaging studies in schizophrenia indicate an excessive brain activity while others report an incoherent brain activity at rest. No direct evidence for the simultaneous presence of both excessive and incoherent brain activity has been established to date. Moreover, it is unclear whether unaffected siblings of schizophrenia patients who share half of the affected patient's genotype also exhibit the excessive and incoherent brain activity that may render them vulnerable to the development of schizophrenia.Methods: 27 pairs of schizophrenia patients and their unaffected siblings, as well as 27 healthy controls, were scanned using gradient-echo echo-planar imaging at rest. By using amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (Reho), we investigated the intensity and synchronization of local spontaneous neuronal activity in three groups.Results: We observed that increased amplitude and reduced synchronization (coherence) of spontaneous neuronal activity were shared by patients and their unaffected siblings. The key brain regions with this abnormal neural pattern in both patients and siblings included the middle temporal, orbito-frontal, inferior occipital and fronto-insular gyrus.Conclusions: This abnormal neural pattern of excessive and incoherent neuronal activity shared by schizophrenia patients and their healthy siblings may improve our understanding of neuropathology and genetic predisposition in schizophrenia. (C) 2016 Elsevier B. V. All rights reserved.