Effectiveness of Seasonal Influenza Vaccines in the United States During a Season With Circulation of All Three Vaccine Strains
Effectiveness of Seasonal Influenza Vaccines in the United States During a Season With Circulation of All Three Vaccine Strains
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DOI：
10.1093/cid/cis574
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发表时间：
2012-10-01
影响因子：
11.8
通讯作者：
Shay, David K.
中科院分区：
文献类型：
--
作者：
Treanor, John J.;Talbot, H. Keipp;Shay, David K.
背景资料。由于流感病毒的抗原性漂移，流感疫苗可能每年重新配制。然而，流行病毒的抗原性与疫苗效力(VE)之间的关系尚不清楚。我们在2010-2011年度对美国流感疫苗的有效性进行了评估。我们进行了一项病例对照研究，比较了流感实时逆转录聚合酶链式反应阳性的急性呼吸道疾病受试者和流感检测阴性的受试者之间的疫苗接种史。年龄=65岁的急性呼吸道疾病患者。美国2010-2011年流感疫苗在所有3种疫苗毒株在抗原性上都与流行病毒相似的季节，在预防医疗护理的流感方面表现出了适度的有效性。继续监测所有年龄段的流感疫苗很重要，特别是在采用新疫苗的情况下。
Background. Influenza vaccines may be reformulated annually because of antigenic drift in influenza viruses. However, the relationship between antigenic characteristics of circulating viruses and vaccine effectiveness (VE) is not well understood. We conducted an assessment of the effectiveness of US influenza vaccines during the 2010-2011 season.Methods. We performed a case-control study comparing vaccination histories between subjects with acute respiratory illness with positive real-time reverse transcription polymerase chain reaction for influenza and influenza test-negative controls. Subjects with acute respiratory illness of = 65 years.Conclusions. The US 2010-2011 influenza vaccines were moderately effective in preventing medically attended influenza during a season when all 3 vaccine strains were antigenically similar to circulating viruses. Continued monitoring of influenza vaccines in all age groups is important, particularly as new vaccines are introduced.