Developmental changes in the excitatory short‐term plasticity at input synapses in the rat inferior colliculus
Developmental changes in the excitatory short‐term plasticity at input synapses in the rat inferior colliculus
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DOI：
10.1111/ejn.14422
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发表时间：
2019-09
影响因子：
3.4
通讯作者：
Mako Kitagawa;T. Sakaba
中科院分区：
文献类型：
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作者：
Mako Kitagawa;T. Sakaba
下丘（IC）是听觉通路中会聚和整合的原始中心。虽然广泛的功能变化发生在听觉脑干的中继突触在发育过程中，IC的变化仍有待研究。在这里，我们已经测量了兴奋性突触后电流（EPSC）的神经元在中央核的IC在刺激的外侧丘系或下丘连合。在听力发作之前，丘系输入表现出短期抑制，而连合输入表现出易化。听力发作后，N-甲基-d-天冬氨酸-EPSC在两种途径中都表现出更快的衰减，而AMPA-EPSC的衰减没有改变。此外，EPSCs在两种途径中的重复刺激期间显示出更恒定的反应。这些发育变化确保了听力开始后更快和更可靠的信号传输到下丘。
The inferior colliculus (IC) is the primal center of convergence and integration in the auditory pathway. Although extensive functional changes are known to occur at the relay synapses in the auditory brainstem during development, the changes in the IC remain to be investigated. Here, we have measured excitatory postsynaptic currents (EPSCs) of the neurons in the central nucleus of the IC in response to stimulation of either the lateral lemniscus or the commissure of the inferior colliculus. Before hearing onset, the lemniscus inputs exhibited short‐term depression, whereas commissural inputs showed facilitation. After hearing onset, the N‐methyl‐d‐aspartate‐EPSCs exhibited faster decay for both pathways, whereas the decay of the AMPA‐EPSCs were unaltered. Furthermore, the EPSCs showed more constant responses during repetitive stimulation in both pathways. These developmental changes ensure faster and more reliable signal transmission to the inferior colliculus after onset of hearing.