The insulinotropic action of gastric inhibitory polypeptide in the perfused isolated rat pancreas.
The insulinotropic action of gastric inhibitory polypeptide in the perfused isolated rat pancreas.
复制标题
胃抑制多肽在灌注的离体大鼠胰腺中的促胰岛素作用。
DOI：
10.1210/endo-99-3-780
复制
发表时间：
1976
期刊：
影响因子：
4.8
通讯作者：
J. Brown
中科院分区：
文献类型：
--
作者：
R. Pederson;J. Brown
胃抑制多肽（GIP）从灌流的离体大鼠胰腺中产生剂量相关的免疫反应性胰岛素（IRI）增加。所用剂量在生理限度内。这种效应是葡萄糖浓度依赖性的，因为存在一个葡萄糖阈值浓度，高于该浓度，GIP发挥促胰岛素作用，并且在固定的GIP浓度下，葡萄糖浓度增加刺激IRI释放超过添加剂的方式。分离并纯化了GIP分子的生物活性片段。GIP是一种促胰岛素激素，符合所有标准。
Gastric inhibitory polypeptide (GIP) produced a dose-related increase in immunoreactive insulin (IRI) from the perfused isolated rat pancreas. The doses employed were within physiological limits. This effect was glucose-concentration-dependent in that there existed a threshold concentration of glucose above which GIP exerted the insulinotropic action, and that, at a fixed concentration of GIP, increased glucose concentrations stimulated IRI release in more than an additive manner. A biologically active fragment of the GIP molecule was isolated and purified. All criteria have been satisfied that GIP is an insulinotropic hormone.