Subtype C is associated with increased vaginal shedding of HIV-1
Subtype C is associated with increased vaginal shedding of HIV-1
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DOI：
10.1086/431514
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发表时间：
2005-08-01
影响因子：
6.4
通讯作者：
Overbaugh, J
中科院分区：
文献类型：
--
作者：
John-Stewart, GC;Nduati, RW;Overbaugh, J
The prevalence of human immunodeficiency virus (HIV)-1 infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1-infected vaginal cells than were those infected with subtype A or D ( odds ratio [ OR], 3.6 [95% confidence interval {CI}, 1.4-8.8]; P p. 006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [ 95% CI,1.1-8.6];). These observations suggest that HIV-1 Pp. 03 subtype influences mucosal shedding of HIV-1.
