Electroencephalographic asymmetries in adolescents with major depression: Influence of comorbidity with anxiety disorders
Electroencephalographic asymmetries in adolescents with major depression: Influence of comorbidity with anxiety disorders
复制标题
DOI：
10.1037/0021-843x.109.4.797
复制
发表时间：
2000-11-01
影响因子：
4.6
通讯作者：
Bruder, GE
中科院分区：
文献类型：
--
作者：
Kentgen, LM;Tenke, CE;Bruder, GE
本研究旨在探讨青少年重度抑郁症（MDD）是否显示异常脑电图（EEG）α不对称性抑郁症的成年人。静息脑电图记录在25个右撇子女性门诊患者（19与MDD，其中11人也有目前的焦虑症：6与焦虑症）和10个非疾病对照。与非疾病对照组相比，患有MDD但无焦虑症的青少年表现出α不对称性，表明右后侧部位的激活程度低于左后侧部位。在MDD患者组中，共病焦虑障碍降低了后α不对称性，支持在青少年MDD区域脑激活研究中评估焦虑的潜在重要性。这些初步结果与成人研究的结果相似，成人研究表明MDD与右侧顶颞叶功能减退相关。
This study examined whether adolescents with major depressive disorder (MDD) display the abnormal electroencephalographic (EEG) alpha asymmetries found in depressed adults. Resting EEG was recorded in 25 right-handed female outpatients (19 with MDD, 11 of whom also had a current anxiety disorder: 6 with anxiety disorders only) and 10 non-ill controls. In contrast to the non-ill controls, adolescents having MDD but no anxiety disorder showed alpha asymmetry indicative of less activation over right than over left posterior sites. Within the MDD patient group, comorbid anxiety disorders reduced the posterior alpha asymmetry, supporting the potential importance of evaluating anxiety in studies of regional brain activation in adolescent MDD. These preliminary findings are similar to those from adult studies that suggest that MDD is associated with right parietotemporal hypoactivation.