RED-BLOOD-CELL MAGNESIUM AND CHRONIC FATIGUE SYNDROME
RED-BLOOD-CELL MAGNESIUM AND CHRONIC FATIGUE SYNDROME
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DOI：
10.1016/0140-6736(91)91371-z
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发表时间：
1991-03-30
期刊：
影响因子：
168.9
通讯作者：
DOWSON, D
中科院分区：
文献类型：
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作者：
COX, IM;CAMPBELL, MJ;DOWSON, D
慢性疲劳综合征 (CFS) 患者的红细胞镁水平较低以及镁治疗将改善此类患者的健康状况的假设分别在一项病例对照研究和一项随机、双盲、安慰剂对照试验中进行了检验。 在病例对照研究中，20 名 CFS 患者的红细胞镁浓度低于 20 名年龄、性别和社会阶层匹配的健康对照受试者（差异 0.1 mmol/l，95% 置信区间 [CI] 0.05 至 0.15）。 在临床试验中，32 名 CFS 患者被随机分配至每周肌注硫酸镁组，持续 6 周（15 名患者）或安慰剂组（17 名）。 根据诺丁汉健康状况的变化判断，接受镁治疗的患者声称能量水平得到改善，情绪状态更好，疼痛减轻。 15 名接受治疗的患者中有 12 名表示他们从治疗中受益，其中 7 名患者的能量评分从最高改善到最低。 相比之下，服用安慰剂的 17 名患者中有 3 名表示感觉更好（差异 62%，95% CI 35 至 90），1 名患者的能量评分更好。 所有服用镁的患者的红细胞镁均恢复正常，但只有 1 名服用安慰剂的患者恢复正常。 研究结果表明，镁可能在慢性疲劳综合症中发挥作用。
The hypotheses that patients with chronic fatigue syndrome (CFS) have low red blood cell magnesium and that magnesium treatment would improve the wellbeing of such patients were tested in a case-control study and a randomised, double-blind, placebo-controlled trial, respectively. In the case-control study, 20 patients with CFS had lower red cell magnesium concentrations than did 20 healthy control subjects matched for age, sex, and social class (difference 0.1 mmol/l, 95% confidence interval [CI] 0.05 to 0.15). In the clinical trial, 32 patients with CFS were randomly allocated either to intramuscular magnesium sulphate every week for 6 weeks (15 patients) or to placebo (17). Patients treated with magnesium claimed to have improved energy levels, better emotional state, and less pain, as judged by changes in the Nottingham health profile. 12 of the 15 treated patients said that they had benefited from treatment, and in 7 patients energy score improved from the maximum to the minimum. By contrast, 3 of the 17 patients on placebo said that they felt better (difference 62%, 95% CI 35 to 90), and 1 patient had a better energy score. Red cell magnesium returned to normal in all patients on magnesium but in only 1 patient on placebo. The findings show that magnesium may have a role in CFS.