Chronic morphine application is protective against cell death in primary human neurons
Chronic morphine application is protective against cell death in primary human neurons
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DOI：
10.1097/wnr.0b013e3283186fd7
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发表时间：
2008-12
期刊：
影响因子：
1.7
通讯作者：
Jiadong Cui;Qiuyue Chen;Long-chuan Yu;Yan Zhang
中科院分区：
文献类型：
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作者：
Jiadong Cui;Qiuyue Chen;Long-chuan Yu;Yan Zhang
吗啡成瘾已成为一个长期、严重的医学和社会问题。为了了解吗啡应用和成瘾的细胞机制，在原代培养的人神经元中检查了慢性吗啡处理的效果。我们的研究结果表明，令人惊讶的是，吗啡保护培养的人神经元对血清剥夺和星形孢菌素诱导的细胞毒性。吗啡下调促凋亡因子Bax水平在培养的人神经元。此外，热休克蛋白70也参与吗啡的保护作用。我们的数据表明，长期应用吗啡可能有利于刺激细胞存活。
Morphine addiction has become a long-time, serious medical and social problem. To understand the cellular mechanisms of morphine application and addiction, the effects of chronic morphine treatments were examined in primary cultured human neurons. Our results show that, surprisingly, morphine protects cultured human neurons against serum deprivation and staurosporine induced cytotoxicity. Morphine downregulates proapoptotic factor Bax levels in cultured human neurons. In addition, heat shock protein 70 is also involved in morphine protection. Our data suggest that chronic morphine application may be beneficial to stimulate cell survival.