Macrophages: Their role, activation and polarization in pulmonary diseases.
Macrophages: Their role, activation and polarization in pulmonary diseases.
复制标题
DOI：
10.1016/j.imbio.2017.11.001
复制
发表时间：
2018-04
期刊：
影响因子：
2.8
通讯作者：
Syed MA
中科院分区：
文献类型：
--
作者：
Arora S;Dev K;Agarwal B;Das P;Syed MA
在血液中循环或连接到不同器官和组织中的巨噬细胞构成了对抗任何疾病的第一道屏障。它们是先天性和获得性免疫、健康组织稳态、血管生成和先天性代谢的最重要控制者。巨噬细胞的两个标志是多样性和可塑性，由于它们获得了一系列摇摆不定的表型。这些表型是对来自组织微环境或微生物或其产物的各种不同刺激的适当同步反应。根据表型，巨噬细胞分为经典活化/（M1）和替代活化/（M2），后者根据基因表达谱进一步细分为M2 a、M2 b、M2 c和M2 d。巨噬细胞表型变态是许多炎症性疾病发生、发展和终止的调节因子。几种转录因子和控制基因表达的其他因子如miRNA在不同疾病的不同点促进巨噬细胞的转化。了解巨噬细胞极化的机制和调节其表型以适应微环境条件可能为我们设计新的治疗策略提供很大的前景。鉴于此，本文综述了巨噬细胞的激活，参与激活的因素沿着巨噬细胞极化对微生物感染、肺毒性、肺损伤和其他炎症性疾病如慢性阻塞性肺发育不良（COPD）、支气管肺发育不良（BPD）、哮喘和脓毒症的反应，沿着现有的努力来开发靶向巨噬细胞生物学这一方面的疗法。
Macrophages, circulating in the blood or concatenated into different organs and tissues constitute the first barrier against any disease. They are foremost controllers of both innate and acquired immunity, healthy tissue homeostasis, vasculogenesis and congenital metabolism. Two hallmarks of macrophages are diversity and plasticity due to which they acquire a wobbling array of phenotypes. These phenotypes are appropriately synchronized responses to a variety of different stimuli from either the tissue microenvironment or – microbes or their products. Based on the phenotype, macrophages are classified into classically activated/(M1) and alternatively activated/(M2) which are further sub-categorized into M2a, M2b, M2c and M2d based upon gene expression profiles. Macrophage phenotype metamorphosis is the regulating factor in initiation, progression, and termination of numerous inflammatory diseases. Several transcriptional factors and other factors controlling gene expression such as miRNAs contribute to the transformation of macrophages at different points in different diseases. Understanding the mechanisms of macrophage polarization and modulation of their phenotypes to adjust to the micro environmental conditions might provide us a great prospective for designing novel therapeutic strategy. In view of the above, this review summarises the activation of macrophages, the factors intricated in activation along with benefaction of macrophage polarization in response to microbial infections, pulmonary toxicity, lung injury and other inflammatory diseases such as chronic obstructive pulmonary dysplasia (COPD), bronchopulmonary dysplasia (BPD), asthma and sepsis, along with the existing efforts to develop therapies targeting this facet of macrophage biology.
登录
查看更多内容
DOI：
10.4049/jimmunol.1202496
发表时间：
2013-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banerjee S;Xie N;Cui H;Tan Z;Yang S;Icyuz M;Abraham E;Liu G
通讯作者：
Liu G
DOI：
10.1152/ajplung.00294.2007
发表时间：
2008-04-01
影响因子：
4.9
作者：
Buckley, S.;Shi, W.;Warburton, D.
通讯作者：
Warburton, D.
DOI：
10.4049/jimmunol.1100500
发表时间：
2011-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ather JL;Ckless K;Martin R;Foley KL;Suratt BT;Boyson JE;Fitzgerald KA;Flavell RA;Eisenbarth SC;Poynter ME
通讯作者：
Poynter ME
影响因子：
20.3
作者：
Biswas, SK;Gangi, L;Sica, A
通讯作者：
Sica, A
影响因子：
2.1
作者：
Cai, Zhi-Gang;Zhang, Shao-Ming;Xu, Xiao-Ping
通讯作者：
Xu, Xiao-Ping