Non-canonical Wnt signaling pathways in hematopoiesis
Non-canonical Wnt signaling pathways in hematopoiesis
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DOI：
10.1007/s12026-009-8116-7
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发表时间：
2010-03-01
影响因子：
4.4
通讯作者：
Nemeth, Michael J.
中科院分区：
文献类型：
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作者：
Kokolus, Kathleen;Nemeth, Michael J.
造血干细胞(HSCs)是一种罕见的细胞群，负责终生生成所有血细胞。为了维持其数量，造血干细胞必须在自我更新和启动造血分化的对立细胞命运之间建立平衡。多种信号通路参与了HSC细胞命运的调控。其中一组通路就是由Wnt配体家族激活的通路。规范的Wnt信号通路利用β-连环素调节基因表达，在造血中的作用已被广泛研究。然而，越来越多的证据表明，其他被称为非典范的Wnt信号通路也发挥了重要作用。在这篇综述中，我们将讨论Wnt信号通路对造血的调节，重点是非规范的Wnt信号通路的潜在功能。
Hematopoietic stem cells (HSCs) are a rare population of cells that are responsible for life-long generation of blood cells of all lineages. In order to maintain their numbers, HSCs must establish a balance between the opposing cell fates of self-renewal and initiation of hematopoietic differentiation. Multiple signaling pathways have been implicated in the regulation of HSC cell fate. One such set of pathways are those activated by the Wnt family of ligands. The function of the canonical Wnt signaling pathway, which utilizes beta-catenin to regulate gene expression, has been extensively studied in hematopoiesis. However, there is a growing body of evidence that the other Wnt signaling pathways, termed non-canonical, also play an important role. In this review, we will discuss the regulation of hematopoiesis by the Wnt signaling pathways, focusing on the potential functions of non-canonical Wnt signaling pathways.