Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone
Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone
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DOI：
10.1523/jneurosci.1014-07.2007
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发表时间：
2007-11-21
影响因子：
5.3
通讯作者：
Sawamoto, Kazunobu
中科院分区：
文献类型：
--
作者：
Hirota, Yuki;Ohshima, Toshio;Sawamoto, Kazunobu
在成年啮齿动物脑的侧脑室侧壁，神经母细胞在脑室下区形成一个广泛的细长细胞聚集体网络，称为链，并向嗅球迁移。调节成神经细胞迁移的分子机制基本上是未知的。在这里，我们报告了一个新的作用，细胞周期蛋白依赖性激酶5（Cdk5），神经元蛋白激酶，在这个过程中。使用在体外和体内条件敲除实验中，我们发现，Cdk5缺失受损的链的形成，速度，方向性，和领先的过程延伸的神经母细胞在细胞自主的方式。这些结果表明，Cdk 5起着重要的作用，神经母细胞迁移在出生后的脑室下区。
At the lateral wall of the lateral ventricles in the adult rodent brain, neuroblasts form an extensive network of elongated cell aggregates called chains in the subventricular zone and migrate toward the olfactory bulb. The molecular mechanisms regulating this migration of neuroblasts are essentially unknown. Here, we report a novel role for cyclin-dependent kinase 5 (Cdk5), a neuronal protein kinase, in this process. Using in vitro and in vivo conditional knock-out experiments, we found that Cdk5 deletion impaired the chain formation, speed, directionality, and leading process extension of the neuroblasts in a cell-autonomous manner. These findings suggest that Cdk5 plays an important role in neuroblast migration in the postnatal subventricular zone.