17 beta-estradiol and smooth muscle cell proliferation in aortic cells of male and female rats
17 beta-estradiol and smooth muscle cell proliferation in aortic cells of male and female rats
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DOI：
10.1006/bbrc.1996.0535
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发表时间：
1996-04-05
影响因子：
3.1
通讯作者：
Luscher, TF
中科院分区：
文献类型：
--
作者：
Espinosa, E;Oemar, BS;Luscher, TF
绝经前或激素替代治疗期间女性心血管疾病的低发病率表明雌激素具有保护作用。机制尚不确定，但可能涉及对脂质、凝血和内皮的影响。血管平滑肌细胞（VSMC）增殖也有助于动脉粥样硬化。因此，我们研究了（17）β-雌二醇（E（2））是否抑制VSMC增殖。将6只雌性和6只雄性Wistar京都大鼠（WKY; 10-12周龄）的VSMC与E（2）和/或胎牛血清（FCS）孵育23小时。单独使用E（2）（10（-9）-10（-5）M）可降低10（-5）M下的[H-3]胸苷摄取（n=8，p
The low incidence of cardiovascular disease in women before menopause or during hormone replacement therapy suggests a protective effect of estrogens. The mechanism(s) are uncertain but may involve effects on lipids, coagulation and the endothelium. Vascular smooth muscle cell (VSMC) proliferation also contributes to atherosclerosis. Hence, we investigated whether (17)beta-estradiol (E(2)) inhibits VSMC proliferation. VSMC of 6 female and 6 male Wistar Kyoto rats (WKY; age 10-12 weeks) were incubated for 23 h with E(2) and/or fetal calf serum (FCS). E(2) (10(-9)-10(-5) M) alone reduced [H-3]thymidine uptake at 10(-5) M (n=8, p