Chronic bronchial suppuration and antineutrophil cytoplasmic antibody (ANCA) positive systemic vasculitis.
Chronic bronchial suppuration and antineutrophil cytoplasmic antibody (ANCA) positive systemic vasculitis.
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慢性支气管化脓和抗中性粒细胞胞浆抗体（ANCA）阳性系统性血管炎。
DOI：
10.1136/pgmj.66.778.669
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发表时间：
1990
影响因子：
5.1
通讯作者：
B. Hoffbrand
中科院分区：
文献类型：
--
作者：
Dimitri Sitara;B. Hoffbrand
两名长期慢性支气管化脓的患者分别出现抗中性粒细胞胞浆抗体（ANCA）阳性韦格纳肉芽肿病和显微镜下多动脉炎。有已发表的证据表明既往化脓性呼吸道疾病与韦格纳肉芽肿病之间存在关联。我们相信，我们的病例提供了进一步的证据，表明慢性肺部感染可能在某些个体发生 ANCA 阳性系统性坏死性血管炎的过程中发挥病因作用。
Two patients with long-standing chronic bronchial suppuration developed antineutrophil cytoplasmic antibody (ANCA) positive Wegener's granulomatosis and microscopic polyarteritis respectively. There is published evidence of an association between previous suppurative respiratory disease and Wegener's granulomatosis. We believe that our cases provide further evidence that chronic lung infection may play an aetiological role in the development of ANCA-positive systemic necrotizing vasculitis in some individuals.