Erratum: Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation.
Erratum: Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation.
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勘误表：表达小清蛋白的中间神经元协调记忆巩固所需的海马网络动力学。
DOI：
10.1038/ncomms16120
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发表时间：
2017
影响因子：
16.6
通讯作者：
Aton,SaraJ
中科院分区：
文献类型：
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作者：
Ognjanovski,Nicolette;Schaeffer,Samantha;Wu,Jiaxing;Mofakham,Sima;Maruyama,Daniel;Zochowski,Michal;Aton,SaraJ
海马区CA1区的活动对于巩固情节记忆是必不可少的，但尚不清楚CA1活动模式如何驱动记忆的形成。我们发现，在单次实验情境恐惧条件反射(CFC)后的几个小时内，快速放电的中间神经元(通常表达小白蛋白(PV))显示出与CA1网络振荡更强的放电一致性。氯氟化碳后对PV+中间神经元的抑制阻断了对记忆巩固的恐惧。这种效应与正常巩固相关的两个网络变化的丧失有关：(1)与睡眠相关的增量(0.5-4 赫兹)、β(4-12 赫兹)和波纹(15 0-2 5 赫兹)振荡；以及(2)CA1神经元功能连接模式的稳定。PV+中间神经元的节律性激活增加了CA1网络的连贯性，导致神经元之间功能连接的强度和稳定性持续增加。我们的结果表明，学习后立即，PV+中间神经元驱动CA1振荡和CA1集合的重新激活，这直接促进了网络的可塑性和长期记忆的形成。
Activity in hippocampal area CA1 is essential for consolidating episodic memories, but it is unclear how CA1 activity patterns drive memory formation. We find that in the hours following single-trial contextual fear conditioning (CFC), fast-spiking interneurons (which typically express parvalbumin (PV)) show greater firing coherence with CA1 network oscillations. Post-CFC inhibition of PV+ interneurons blocks fear memory consolidation. This effect is associated with loss of two network changes associated with normal consolidation: (1) augmented sleep-associated delta (0.5–4 Hz), theta (4–12 Hz) and ripple (150–250 Hz) oscillations; and (2) stabilization of CA1 neurons’ functional connectivity patterns. Rhythmic activation of PV+ interneurons increases CA1 network coherence and leads to a sustained increase in the strength and stability of functional connections between neurons. Our results suggest that immediately following learning, PV+ interneurons drive CA1 oscillations and reactivation of CA1 ensembles, which directly promotes network plasticity and long-term memory formation.