Molecular Cloning and Characterization of a cDNA Encoding a Novel Basic Helix-Loop-Helix Protein Structurally Related to NeuroD/BHF1
Molecular Cloning and Characterization of a cDNA Encoding a Novel Basic Helix-Loop-Helix Protein Structurally Related to NeuroD/BHF1
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编码与 NeuroD/BHF1 结构相关的新型基本螺旋-环-螺旋蛋白的 cDNA 的分子克隆和表征
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
H. Ohkubo
中科院分区：
文献类型：
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作者：
M. Yasunami;Kazuo Suzuki;H. Maruyama;H. Kawakami;Y. Nagai;M. Hagiwara;H. Ohkubo
我们克隆了一种新的碱性螺旋-环-螺旋蛋白--神经相关因子(NDRF)--cDNA.NDRF由383个氨基酸组成，与NeuD和MATH-2/NEX-1的同源性分别为53.4%和52.2%。NDRF mRNA存在于12日龄小鼠胚胎的大脑中，并定位于成年大脑的某些区域，如海马体、齿状回和小脑。因此，NDRF的结构和表达模式与Neurd和Math-2/NEX-1相似但又不同，提示NDRF可能作为神经D家族的新成员在神经发育和可塑性中发挥不同的作用。
We cloned a novel basic helix-loop-helix protein, NDRF (NeuroD-related factor), cDNA. NDRF contains 383 amino acids and exhibits 53.4% and 52.2% sequence identity to NeuroD and MATH-2/NEX-1, respectively. NDRF mRNA appears in the brain of 12-day-old mouse embryos and is localized in certain regions of the adult brain, such as the hippocampus, dentate gyrus and cerebellum. Thus, the structure and expression patterns of NDRF are similar to but distinct from those of NeuroD and MATH-2/NEX-1, suggesting that NDRF may play distinct roles in neural development and plasticity as a novel member of the NeuroD family.