A versatile multimodal optical modality based on Brillouin light scattering and photoacoustic effect.
A versatile multimodal optical modality based on Brillouin light scattering and photoacoustic effect.
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基于布里渊光散射和光声效应的多功能多模态光学模态。
DOI：
10.1101/2023.03.10.532144
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zhang,Jitao
中科院分区：
文献类型：
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作者：
Shi,Chenjun;Yan,Yan;Mehrmohammadi,Mohammad;Zhang,Jitao
多模态光学技术对于材料性质的综合表征是有用的。在这项工作中，我们开发了一种新的，据我们所知，多模态技术，可以同时测量样品的机械，光学和声学特性的子集，并基于布里louin （Br）和光声（PA）显微镜的集成。该方法可以从样品中获得共配准的Br和PA信号。重要的是，使用声速和布里渊位移的协同测量，该模态提供了一种量化光学折射率的新方法，折射率是材料的基本属性，是两种技术都无法单独获得的。作为概念验证，我们展示了集成两种模式的可行性，并在煤油和CuSO_4水溶液制成的合成模体中获得了共定位的Br和时间分辨的PA信号。此外，我们测量了生理盐水溶液的折射率值并验证了结果。与先前报道的数据相比，相对误差为0.3%。这进一步使我们能够直接量化样品的纵向模量与共定位布里渊位移。虽然目前的工作范围仅限于首次引入Br-PA组合设置，但我们设想这种多模态模态可以为材料性能的多参数分析开辟新的途径。
Multimodal optical techniques are useful for the comprehensive characterization of material properties. In this work, we developed a new, to the best of our knowledge, multimodal technology that can simultaneously measure a subset of mechanical, optical, and acoustical properties of the sample and is based on the integration of Brillouin (Br) and photoacoustic (PA) microscopy. The proposed technique can acquire co-registered Br and PA signals from the sample. Importantly, using synergistic measurements of the speed of sound and Brillouin shift, the modality offers a new approach to quantifying the optical refractive index, which is a fundamental property of a material and is not accessible by either technique individually. As a proof of concept, we demonstrated the feasibility of integrating the two modalities and acquired the colocalized Br and time-resolved PA signals in a synthetic phantom made out of kerosene and CuSO_4 aqueous solution. In addition, we measured the refractive index values of saline solutions and validated the result. Comparison with previously reported data showed a relative error of 0.3%. This further allowed us to directly quantify the longitudinal modulus of the sample with the colocalized Brillouin shift. While the scope of the current work is limited to introducing the combined Br-PA setup for the first time, we envision that this multimodal modality could open a new path for the multi-parametric analysis of material properties.