Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage
Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage
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DOI：
10.1038/12222
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发表时间：
1999-09-01
影响因子：
25
通讯作者：
Phelps, EA
中科院分区：
文献类型：
--
作者：
Chun, MM;Phelps, EA
海马体和邻近的内侧颞叶结构在记忆系统中的作用一直备受争议。在这里，我们在人类身上展示了这些神经结构对于编码来自环境的隐含上下文信息是重要的。我们使用了情境线索任务，其中重复的视觉情境促进了对嵌入目标对象的视觉搜索。我们任务的一个重要特征是背景信息的记忆痕迹是有意识意识无法获得的，因此可以被归类为内隐的。有内侧颞叶系统损害的健忘症患者内隐知觉/技能学习正常，但内隐背景学习受损。我们的结果表明，人类的内侧时间记忆系统对于学习语境信息是重要的，这需要多个线索的绑定。
The role of the hippocampus and adjacent medial temporal lobe structures in memory systems has long been debated. Here we show in humans that these neural structures are important for encoding implicit contextual information from the environment. We used a contextual cuing task in which repeated visual context facilitates visual search for embedded target objects. An important feature of our task is that memory traces for contextual information were not accessible to conscious awareness, and hence could be classified as implicit. Amnesic patients with medial temporal system damage showed normal implicit perceptual/skill learning but were impaired on implicit contextual learning. Our results demonstrate that the human medial temporal memory system is important for learning contextual information, which requires the binding of multiple cues.