Retinal blood flow autoregulation in response to an acute increase in blood pressure.
Retinal blood flow autoregulation in response to an acute increase in blood pressure.
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DOI：
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发表时间：
1986-05
影响因子：
4.4
通讯作者：
F. Robinson;C. Riva;J. Grunwald;B. Petrig;S. Sinclair
中科院分区：
文献类型：
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作者：
F. Robinson;C. Riva;J. Grunwald;B. Petrig;S. Sinclair
应用无创激光多普勒测速(LDV)技术结合视网膜血管大小测量，研究了三名血压正常的健康志愿者的视网膜循环对系统血压急性升高的反应。采用等长运动诱导大鼠动脉压急剧升高。在平均臂动脉血压升高到115毫米汞柱之前，视网膜血流量没有可检测到的变化，这意味着平均血压比基准值上升了41%。超过此值，血流量会随着血压的进一步升高而增加。眼动脉压和臂动脉压之间的平行升高表明，在上述压力范围内观察到的视网膜血流调节是通过增加视网膜血管阻力实现的，而不是通过作用于维持恒定的眼血流灌注压的机制实现的。
The response of the retinal circulation to an acute elevation in systemic blood pressure was studied in three healthy normotensive volunteers using the noninvasive laser Doppler velocimetry (LDV) technique combined with retinal vessel size measurements. Isometric exercise was employed to induce the acute rise in arterial pressure. There was no detectable change in retinal blood flow until the mean brachial artery blood pressure was elevated to an average of 115 mm Hg, which represented an average rise in mean blood pressure of 41% above baseline values. Above this value, blood flow increased along with further increments in blood pressure. The parallel rise between the ophthalmic artery pressure and the brachial artery pressure indicates that the regulation of retinal blood flow observed in the above mentioned pressure range is achieved through an increase in retinal vascular resistance rather than by a mechanism that would act to maintain a constant ocular perfusion pressure.