Multicomponent protein patterning of material surfaces
Multicomponent protein patterning of material surfaces
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DOI：
10.1039/b926690a
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发表时间：
2010-01-01
影响因子：
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通讯作者：
Lendlein, Andreas
中科院分区：
文献类型：
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作者：
Ganesan, Ramakrishnan;Kratz, Karl;Lendlein, Andreas
微尺度和纳米尺度的蛋白质图案已经获得了显著的技术兴趣。虽然用于单组分蛋白质图案化的某些技术是成熟的，但多组分蛋白质图案化方法是当前深入研究的主题，其可以实现复杂的生物传感器系统并扩展蛋白质-蛋白质和蛋白质-细胞或细胞-细胞相互作用的知识。只有少数图案化方法适合于实现三维图案，这对于许多应用是必不可少的，例如在用于再生疗法的支架的设计中。在这篇专题文章中，介绍了创建多组分蛋白质图案的代表性方法，并讨论了它们在生物材料表面为细胞定制微环境的潜力。
Micro- and nano-scale protein patterns have gained significant technological interest. While certain techniques for single-component protein patterning are well-established, multicomponent protein patterning approaches are a current topic of intensive research, which might enable complex biosensor systems and expand the knowledge in protein-protein and protein-cell or cell-cell interactions. Only a few patterning methods are suitable for the realization of three dimensional patterns, which are essential for many applications e.g. in the design of scaffolds for regenerative therapies. In this feature article representative approaches for creating multicomponent protein patterning are presented and their potential for tailoring microenvironments for cells on biomaterials surfaces is discussed.