Association of COVID-19 pandemic-related concern and health routine changes with functioning among individuals with systemic lupus erythematosus.
Association of COVID-19 pandemic-related concern and health routine changes with functioning among individuals with systemic lupus erythematosus.
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DOI：
10.1136/lupus-2022-000658
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发表时间：
2022-03
影响因子：
3.9
通讯作者：
Bowling CB
中科院分区：
文献类型：
--
作者：
Plantinga LC;Hoge C;Dunlop-Thomas C;Pearce BD;Lim SS;Drenkard C;Bowling CB
检查与大流行相关的问题是否与SLE患者的身体功能、社区流动性和认知有关。受试者被招募(2020年10月6日至2021年11月11日)参加这项横断面研究，研究对象来自亚特兰大大都市确诊为SLE的人群队列，作为正在进行的辅助研究的一部分。与大流行病有关的问题(对大流行的关注(非常担心)；体力活动和睡眠的变化(更少与更多/相同)；难以获得食物和药物以及获得常规护理(有没有))都是自我报告的。自我报告的身体功能以及情景和工作记忆表现被报告为t分(50分=总体平均值，10分差=1 SD)和社区流动性分数从0到120，分数越高，代表所有领域的功能都更好。得分的差异通过t检验和年龄调整、性别调整和种族调整的线性回归来评估。在245名参与者(平均年龄46岁；95%女性，77%黑人)中，对于那些报告担心大流行、体力活动和睡眠减少、难以获得食物和药物以及获得常规护理的人来说，身体机能t分(平均=44分)一直较低(下降3-5分)。同样，这些人的社区流动性得分(平均为48分)较低(低10-20分)。大流行相关问题在情节记忆和工作记忆t分数(平均值分别为50 和47)方面没有显著差异。我们发现，在那些报告更多对大流行的担忧或对健康日常生活的更大干扰的人中，身体功能和社区流动性较低，但认知能力较低。未来的研究应该探索对这些患有SLE的脆弱患者进行干预，他们已经遭受了不成比例的功能损害，以维持功能并防止在危机时期出现不良后果。
To examine whether pandemic-related issues were associated with physical functioning, community mobility and cognition among individuals with SLE. Participants were recruited (6 October 2020–11 November 2021) for this cross-sectional study from a population-based cohort of individuals with validated SLE in metropolitan Atlanta, as part of an ongoing ancillary study. Pandemic-related issues (concern about the pandemic (very vs somewhat/not at all concerned); changes in physical activity and sleep (less vs more/same); difficulty obtaining food and medications and accessing routine care (any vs none)) were self-reported. Self-reported physical functioning and episodic and working memory performance were reported as t-scores (such that a score of 50=population mean and a 10-point difference=1 SD) and community mobility scores ranged from 0 to 120, with higher scores representing better functioning for all domains. Differences in scores were assessed via t-tests and age-adjusted, sex-adjusted and race-adjusted linear regression. Among 245 participants (mean age, 46 years; 95% female, 77% black), physical functioning t-scores (mean=44) were consistently lower (by 3–5 points) for those who reported concern about the pandemic, less physical activity and sleep, difficulty obtaining food and medications, and accessing routine care. Similarly, community mobility scores (mean=48) were lower (by 10–20 points) for these individuals. There were no substantial differences in episodic memory and working memory t-scores (mean=50 and 47, respectively) by pandemic-related issues. We found that physical functioning and community mobility, but not cognition, were lower among those who reported more concern about the pandemic or greater disruptions to health routines. Future studies should explore interventions among these vulnerable individuals with SLE, who already disproportionately suffer from functional impairment, to maintain functioning and prevent adverse outcomes during times of crisis.
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影响因子：
6.3
作者：
Hoffman, Geoffrey J.;Malani, Preeti N.;Kullgren, Jeffrey T.
通讯作者：
Kullgren, Jeffrey T.
影响因子：
5.2
作者：
Perracini MR;de Amorim JSC;Lima CA;da Silva A;Trombini-Souza F;Pereira DS;Pelicioni PHS;Duim E;Batista PP;Dos Santos RB;de Lima MDCC;REMOBILIZE Research Network (CANSORT-SCI)
通讯作者：
REMOBILIZE Research Network (CANSORT-SCI)
DOI：
10.1093/gerona/glaa274
发表时间：
2021-03-01
影响因子：
5.1
作者：
Rantanen, Taina;Eronen, Johanna;Newman, Anne B.
通讯作者：
Newman, Anne B.
影响因子：
3.2
作者：
Peel, C;Baker, PS;Allman, RM
通讯作者：
Allman, RM
影响因子：
4.7
作者：
Plantinga, Laura;Tift, Benjamin D.;Drenkard, Cristina
通讯作者：
Drenkard, Cristina