Using adult mosquitoes to transfer insecticides to Aedes aegypti larval habitats
Using adult mosquitoes to transfer insecticides to Aedes aegypti larval habitats
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DOI：
10.1073/pnas.0901369106
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发表时间：
2009-07-14
影响因子：
11.1
通讯作者：
Morrison, Amy C.
中科院分区：
文献类型：
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作者：
Devine, Gregor J.;Zamora Perea, Elvira;Morrison, Amy C.
病媒控制是防治蚊媒疾病的关键手段，也是应对登革热传播的唯一工具，登革热是一种目前尚无疫苗、预防措施或治疗方法的疾病。最有效的蚊子控制方法包括针对成年人或青少年的各种杀虫工具。它们的成功实施取决于影响到尽可能大比例的媒介人口。我们展示了一种控制策略，极大地提高了实现水生蚊子栖息地高覆盖率的效率。该方法利用成年蚊子作为杀虫剂转移的媒介，利用它们的基本行为在休息和产卵地点之间传播保幼激素类似物(JHA)。在亚马逊城市(秘鲁伊基托斯)进行的一系列实地试验表明，JHA传播站仅在可用休息区的3%-5%处放置，几乎完全覆盖了哨兵水生栖息地。在这些地点发育的埃及伊蚊幼虫队列中，95%-100%的幼虫死亡率高于控制死亡率。在试验期间，成虫羽化的总体减少了42%-98%。一个确定性的模拟模型预测了与我们的观察结果一致的覆盖率扩大，并强调了杀虫剂的残留活性对这项技术的重要性。
Vector control is a key means of combating mosquito-borne diseases and the only tool available for tackling the transmission of dengue, a disease for which no vaccine, prophylaxis, or therapeutant currently exists. The most effective mosquito control methods include a variety of insecticidal tools that target adults or juveniles. Their successful implementation depends on impacting the largest proportion of the vector population possible. We demonstrate a control strategy that dramatically improves the efficiency with which high coverage of aquatic mosquito habitats can be achieved. The method exploits adult mosquitoes as vehicles of insecticide transfer by harnessing their fundamental behaviors to disseminate a juvenile hormone analogue (JHA) between resting and oviposition sites. A series of field trials undertaken in an Amazon city (Iquitos, Peru) showed that the placement of JHA dissemination stations in just 3-5% of the available resting area resulted in almost complete coverage of sentinel aquatic habitats. More than control mortality occurred in 95-100% of the larval cohorts of Aedes aegypti developing at those sites. Overall reductions in adult emergence of 42-98% were achieved during the trials. A deterministic simulation model predicts amplifications in coverage consistent with our observations and highlights the importance of the residual activity of the insecticide for this technique.