Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study.
Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study.
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DOI：
10.1002/oby.21258
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发表时间：
2016-01
期刊：
影响因子：
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通讯作者：
Lanphear BP
中科院分区：
文献类型：
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作者：
Braun JM;Chen A;Romano ME;Calafat AM;Webster GM;Yolton K;Lanphear BP
研究产前全氟烷基物质（PFAS）暴露与氟聚合物生产厂下游妇女所生儿童肥胖之间的关系。数据来自辛辛那提，OH的前瞻性队列（HOME研究）。我们测量了产前血清样本中的全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟壬酸（PFNA）和全氟己烷磺酸（PFHxS）。根据PFAS浓度，我们估计了8岁时体重指数z评分（BMI）、腰围和体脂（n=204）以及2-8岁之间BMI（n=285）的差异。在前两个PFOA三分位数的妇女所生的孩子在8岁时比第一个三分位数的孩子有更大的肥胖。例如，与第一个三等分线的儿童相比，第二个三等分线的儿童（4.3; 95% CI：1.7，6.9）和第三个三等分线的儿童（2.2; 95% CI：-0.5，4.9）的腰围（cm）更高。与第一个三分位数的儿童相比，前两个PFOA三分位数的儿童在2-8岁时的BMI增加也更大（p<0.05）。PFOS、PFNA和PFHxS与肥胖症无关。在这个队列中，较高的产前血清PFOA浓度与8岁时的肥胖程度和2-8岁之间BMI的快速增加有关。
To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant. Data are from a prospective cohort in Cincinnati, OH (HOME Study). We measured perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids in prenatal serum samples. We estimated differences in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n=204) and BMI between 2–8 years of age (n=285) according to PFAS concentrations. Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI:1.7, 6.9) and 3rd tercile (2.2; 95% CI:−0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2–8 years compared to children in the 1st tercile (p<0.05). PFOS, PFNA and PFHxS were not associated with adiposity. In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2–8 years.