Years of life that could be saved from prevention of hepatocellular carcinoma
Years of life that could be saved from prevention of hepatocellular carcinoma
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DOI：
10.1111/apt.13554
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发表时间：
2016-04-01
影响因子：
7.6
通讯作者：
Pinna, A. D.
中科院分区：
文献类型：
--
作者：
Cucchetti, A.;Trevisani, F.;Pinna, A. D.
背景肝细胞癌（HCC）在世界范围内引起过早死亡和预期寿命损失.它的一级和二级预防可以导致大量的生命年saved.AimTo评估多少年的生命是失去后HCC diagnosis.MethodsData从5346例首次HCC诊断被用来估计寿命和肿瘤发病后失去的生命年数，使用半参数外推有作为参考的年龄，性别和发病年份匹配的人群来自国家生命表。结果在1986年至2014年期间，HCC导致每个患者平均损失11.5年的生命。最年轻的四分之一年龄组（18-61岁）的寿命损失最多，约占预防可获得的总体效益的41%。HCC管理的进步使生命年数从1986-1999年的12.6年逐渐减少到2000-2006年的10.7年和2007-2014年的7.4年。目前，当单个肿瘤
BackgroundHepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved.AimTo assess how many years of life are lost after HCC diagnosis.MethodsData from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables.ResultsBetween 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour