Striatal dopaminergic modulation of reinforcement learning predicts reward-oriented behavior in daily life
Striatal dopaminergic modulation of reinforcement learning predicts reward-oriented behavior in daily life
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DOI：
10.1016/j.biopsycho.2017.04.014
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发表时间：
2017-07-01
影响因子：
2.6
通讯作者：
Myin-Germeys, Inez
中科院分区：
文献类型：
--
作者：
Kasanova, Zuzana;Ceccarini, Jenny;Myin-Germeys, Inez
人类的许多行为都是由奖励驱动的。临床前神经生理学和临床正电子发射断层扫描（PET）研究表明纹状体相多巴胺（DA）释放是奖励处理的主要调节剂。然而，实验奖励诱导的纹状体DA释放与对自然奖励的反应之间的关系，以及这些发现的功能相关性，一直是难以捉摸的。因此，我们首次将16名健康志愿者在概率强化学习（RL）任务期间的DA D-2/3受体[F-18]假骄傲PET与日常生活中奖励相关行为的为期6天的生态瞬时评估（EMA）结合起来。我们在双侧壳核、尾状核和腹侧纹状体中发现了显著的奖励诱导的DA释放，其程度与RL任务中所有区域的更好行为表现有关。此外，在右侧尾状核和腹侧纹状体中，奖励诱导的DA释放程度的个体差异调节了积极参与一种行为的倾向，如果这种行为之前被认为是愉快的。这项研究表明纹状体奖励相关的DA释放与生态相关的奖励导向行为之间存在联系，为探索最佳动机驱动和受损动机驱动的能量基础提供了途径。
Much human behavior is driven by rewards. Preclinical neurophysiological and clinical positron emission tomography (PET) studies have implicated striatal phasic dopamine (DA) release as a primary modulator of reward processing. However, the relationship between experimental reward-induced striatal DA release and responsiveness to naturalistic rewards, and therefore functional relevance of these findings, has been elusive.We therefore combined, for the first time, a DA D-2/3 receptor [F-18] fallypride PET during a probabilistic reinforcement learning (RL) task with a six day ecological momentary assessments (EMA) of reward-related behavior in the everyday life of 16 healthy volunteers. We detected significant reward-induced DA release in the bilateral putamen, caudate nucleus and ventral striatum, the extent of which was associated with better behavioral performance on the RL task across all regions. Furthermore, individual variability in the extent of reward-induced DA release in the right caudate nucleus and ventral striatum modulated the tendency to be actively engaged in a behavior if the active engagement was previously deemed enjoyable. This study suggests a link between striatal reward-related DA release and ecologically relevant reward-oriented behavior, suggesting an avenue for the inquiry into the DAergic basis of optimal and impaired motivational drive.