Innate antiviral responses are induced by TLR3 and TLR4 ligands in chicken tracheal epithelial cells: Communication between epithelial cells and macrophages
Innate antiviral responses are induced by TLR3 and TLR4 ligands in chicken tracheal epithelial cells: Communication between epithelial cells and macrophages
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DOI：
10.1016/j.virol.2019.06.003
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发表时间：
2019-08-01
期刊：
影响因子：
3.7
通讯作者：
Sharif, Shayan
中科院分区：
文献类型：
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作者：
Barjesteh, Neda;Taha-Abdelaziz, Khaled;Sharif, Shayan
鸡的上呼吸道是包括禽流感病毒（AIV）在内的呼吸道病原体的入口。关于气道上皮细胞在鸡气管中诱导抗病毒反应中的作用的信息很少。更好地了解这些细胞在先天性反应启动中的作用，可能会改善控制病毒感染的预防或治疗策略。本研究的目的是表征TLR配体诱导的鸡气管上皮细胞（cTECs）的抗病毒天然反应。结果表明，用TLR配体刺激cTEC诱导抗病毒应答，随后减少AIV在cTEC中的复制。此外，刺激的cTEC能够影响其他细胞如巨噬细胞的功能。总体而言，这些结果提供了证据，证明cTEC在TLR配体刺激后通过IRF 7和NF-κ B信号传导途径产生抗病毒应答，导致其他细胞如巨噬细胞的活化。
The chicken upper respiratory tract is the portal of entry for respiratory pathogens including avian influenza virus (AIV). There is a paucity of information about the role of airway epithelial cells in the induction of antiviral responses in the chicken trachea. A better understanding of the role of these cells in the initiation of innate responses may improve prophylactic or therapeutic strategies for control of viral infections. The present study aimed to characterize antiviral innate responses in chicken tracheal epithelial cells (cTECs) induced by TLR ligands. The results demonstrated that stimulation of cTECs with TLR ligands induced antiviral responses, and subsequently reduced the replication of AIV in cTECs. Additionally, stimulated cTECs were able to influence the function of other cells such as macrophages. Overall, these results provided evidence that cTECs mount antiviral responses after stimulation with TLR ligands through IRF7 and NF-kappa B signaling pathways, leading to activation of other cells, such as macrophages.