Regulation of permeability barrier homeostasis
Regulation of permeability barrier homeostasis
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DOI：
10.1016/j.clindermatol.2011.08.008
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Denda, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Feingold, Kenneth R.;Denda, Mitsuhiro
皮肤的一个主要功能是为水和电解质的运动提供屏障，这是陆地环境中生命所必需的。这种渗透性屏障局限于角质层，由细胞外富含脂质的层状膜介导，层状颗粒细胞通过层状体的分泌将其输送到细胞外间隙。大量的因素已被证明可以调节这种渗透性屏障的形成。具体来说，由于表皮颗粒层钙含量的降低，加速了片层体的分泌和通透性屏障的形成。此外，细胞因子和生长因子的表达增加以及核激素受体（过氧化物酶体增殖激活受体、肝X受体、维生素D受体）的激活加速了通透性屏障的形成。相反，一氧化氮、蛋白酶激活受体2的激活、糖皮质激素和睾酮抑制渗透性屏障的形成。各种因素调节渗透率屏障形成的能力允许更精确和细致的调节。Elsevier Inc.出版。
A major function of the skin is to provide a barrier to the movement of water and electrolytes, which is required for life in a terrestrial environment. This permeability barrier is localized to the stratum corneum and is mediated by extracellular lipid-enriched lamellar membranes, which are delivered to the extracellular spaces by the secretion of lamellar bodies by stratum granulosum cells. A large number of factors have been shown to regulate the formation of this permeability barrier. Specifically, lamellar body secretion and permeability barrier formation are accelerated by decreases in the calcium content in the stratum granulosum layer of the epidermis. In addition, increased expression of cytokines and growth factors and the activation of nuclear hormone receptors (peroxisome proliferator-activated receptors, liver X receptors, vitamin D receptor) accelerate permeability barrier formation. In contrast, nitric oxide, protease-activated receptor 2 activation, glucocorticoids, and testosterone inhibit permeability barrier formation. The ability of a variety of factors to regulate permeability barrier formation allows for a more precise and nuanced regulation. Published by Elsevier Inc.