Environmental pollution and risk of psychotic disorders: A review of the science to date
Environmental pollution and risk of psychotic disorders: A review of the science to date
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DOI：
10.1016/j.schres.2016.10.003
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发表时间：
2017-03-01
影响因子：
4.5
通讯作者：
Compton, Michael T.
中科院分区：
文献类型：
--
作者：
Attademo, Luigi;Bernardini, Francesco;Compton, Michael T.
环境污染是一个全球性问题，对公众健康有着各种各样的重大影响。虽然许多环境问题（如例如，虽然已经确定了精神分裂症和其他精神障碍的非遗传性风险因素，但对污染作为一种可能的风险因素的研究相对较少。尽管基因与环境的相互作用和表观遗传机制现在被认为是精神分裂症病因学的可能方面，而且污染可能潜在地介导城市出生/抚养与风险升高之间的关联。我们进行了文献回顾，以总结和综合这方面的工作。我们确定了13篇研究报告和16篇综述文章。根据这一领域的现有知识和对精神分裂症病理生理学的了解，暴露于外源性重金属（如铅和镉）、空气污染成分（如颗粒物、氮氧化物和硫氧化物）、有机溶剂以及环境污染的其他成分可能是组成原因。从细胞水平到流行病学水平的进一步研究显然是必要的。如果因果关系得到证实，旨在减少人类暴露于环境污染的政策的加强可能会减少精神分裂症和其他精神疾病的负担。(C)2016年爱思唯尔B。V.保留所有权利。
Environmental pollution is a global problem with diverse and substantial public health implications. Although many environmental (i. e., non-genetic) risk factors for schizophrenia and other psychotic disorders have been identified, there has been comparatively little research on pollution as a possible risk factor. This is despite the fact that gene-by-environment interactions and epigenetic mechanisms are now recognized as likely facets of the etiology of schizophrenia, and the fact that pollution could potentially mediate the association between urban birth/ upbringing and elevated risk. We conducted a reviewof the literature to date in order to summarize and synthesize work in this area. We identified 13 research reports and 16 review articles. Based on the extant knowledge in this area and what is known about the pathophysiology of schizophrenia, it is feasible that exposure to xenobiotic heavymetals such as lead and cadmium, constituents of air pollution such as particulatematter and nitrogen and sulfur oxides, organic solvents, and other constituents of environmental pollution could be component causes. Further research-from the cellular to epidemiological levels-is clearly needed. If causation is proven, enhancements of policy intended to reduce human exposure to environmental pollution could reduce the burden of schizophrenia and possibly other mental illnesses. (C) 2016 Elsevier B. V. All rights reserved.