Human embryonic stem cells: A potential source for cellular therapy
Human embryonic stem cells: A potential source for cellular therapy
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DOI：
10.1111/j.1600-6135.2004.0345.x
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发表时间：
2004-02-01
影响因子：
8.8
通讯作者：
Itskovitz-Eldor, J
中科院分区：
文献类型：
--
作者：
Gerecht-Nir, S;Itskovitz-Eldor, J
许多人类退行性疾病反映了正常情况下不能修复或替换的细胞受损，如糖尿病、帕金森病、肝功能衰竭和充血性心力衰竭。对动物和人类的初步研究表明，这些疾病可能可以通过移植健康细胞来治疗。这类细胞可以通过胚胎干细胞的体外培养获得，胚胎干细胞能够分化为多种细胞类型。这篇综述讨论了人类胚胎干细胞(HES)的来源、维持和安全性的应用方法，以及围绕其可能的细胞治疗来源的伦理问题。HES细胞在细胞治疗中有着广泛的应用，但本文着重介绍了心血管修复、HES细胞来源的心肌细胞、血管前体细胞的产生和特性以及衍生细胞的分化。
Many degenerative human diseases reflect damage to cells that are not normally repaired or replaced, such as diabetes, Parkinson's disease, hepatic failure and congestive heart failure. Preliminary studies in animals and humans have suggested that these diseases may be treatable by transplantation of healthy cells. Such cells may be obtained by in vitro culture of embryonic stem cells, which are capable of differentiating into many cell types. This review discusses applicative approaches for the derivation, maintenance and safety of human embryonic stem (hES) cells as well as ethical concerns surrounding their possible source for cellular therapy. hES cells offer broad application in cellular therapy; however, this review specifically emphasizes on cardiovascular repair, generation and characterization of hES cell-derived cardiomyocytes, vascular progenitors and differentiation of derivatives.