1-Hz Repetitive Transcranial Magnetic Stimulation over the Posterior Parietal Cortex Modulates Spatial Attention.
1-Hz Repetitive Transcranial Magnetic Stimulation over the Posterior Parietal Cortex Modulates Spatial Attention.
复制标题
对后顶叶皮质进行 1 Hz 重复经颅磁刺激可调节空间注意力。
DOI：
10.3389/fnhum.2016.00038
复制
发表时间：
2016
影响因子：
2.9
通讯作者：
Lin T
中科院分区：
文献类型：
--
作者：
Xu GQ;Lan Y;Zhang Q;Liu DX;He XF;Lin T
损伤和神经成像研究表明，后顶叶皮质(PPC)区域与视觉空间注意有关。本研究的目的是探讨1赫兹重复经颅磁刺激(RTMS)引起的短暂顶叶损害对空间注意的潜在影响。我们对50名健康受试者进行了注意网络测试(ANT)，首先对右侧或左侧PPC进行rTMS检查。在ANT测试中，右侧顶叶rTMS，而不是左侧PPC rTMS，导致在空间线索后对目标呈现的平均反应时(RT)显著减慢。在无线索、中心线索和双线索条件下，以及每种侧翼类型下，rTMS对平均反应时均无显著影响。此外，在rTMS到右侧PPC后，测试对象在与警报和定向相关的网络中表现出缺陷，而在rTMS到左侧PPC之后，他们表现出改善。这些发现表明，正确的PPC在空间定向和警报活动中起着重要的作用。我们解释说，左侧PPC在低频rTMS后警示和空间定向功能的增强反映了右侧PPC通过大脑半球间抑制帐户的去抑制。
Lesion and neuroimaging studies have suggested that regions in the posterior parietal cortex (PPC) are involved in visual spatial attention. The aim of this study was to investigate the potential effects on spatial attention resulting from a transient parietal impairment induced by 1-Hz repetitive transcranial magnetic stimulation (rTMS). We examined 50 healthy subjects using the attention network test (ANT) after first applying rTMS to right or left PPC. The right parietal rTMS, but not left PPC rTMS, caused a significant slowing in the mean reaction time (RT) to target presentation following a spatial cue during the ANT test. There were no significant effects of rTMS on mean RT under the no-cue, center-cue, and double-cue conditions, or for each flanker type among the experimental groups. Moreover, after rTMS to the right PPC, test subjects displayed deficits in networks related to alerting and orienting, whereas they exhibited improvement following rTMS to the left PPC. These findings indicate that the right PPC serves an important function in spatial orienting and the alerting activities. We interpreted the enhancement in alerting and spatial orienting function following low-frequency rTMS of left PPC as reflecting a disinhibition of right PPC via an inter-hemispheric inhibition account.