New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii.
New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii.
复制标题
新的佐剂可以使大肠杆菌素对鲍曼尼菌的较低剂量。
DOI：
10.1021/acsinfecdis.8b00103
复制
发表时间：
2018-09-14
影响因子：
5.3
通讯作者：
Melander C
中科院分区：
文献类型：
--
作者：
Minrovic BM;Jung D;Melander RJ;Melander C
Antibiotic resistance has become increasingly prevalent over the past few decades, and this combined with a dearth in the development of new classes of antibiotics to treat multidrug resistant Gram-negative infections has led to a significant global health problem and the increased usage of colistin as the last resort antibiotic. Colistin, however, presents dose dependent toxicity in the clinic. One potential approach to combatting this problem is the use of an antibiotic adjuvant, a compound that is non-toxic to the bacteria, that enhances the potency of colistin and ultimately allows for reducing dosing. Herein, we present a new urea-containing class of 2-aminoimidazole based adjuvants that potentiates colistin activity against colistin-sensitive Acinetobacter baumannii. Lead compounds enabled 1000-fold reduction in the minimum inhibitory concentration of colistin in vitro, and showed efficacy in a Galleria mellonella infection model, representing the first step towards validating the potential of employing these adjuvants to lower colistin dosage.
