Peripheral cannabinoids attenuate carcinoma-induced nociception in mice
Peripheral cannabinoids attenuate carcinoma-induced nociception in mice
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DOI：
10.1016/j.neulet.2007.12.053
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发表时间：
2008-03-12
影响因子：
2.5
通讯作者：
Schmidt, Brian L.
中科院分区：
文献类型：
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作者：
Guerrero, Andre V.;Quang, Phuong;Schmidt, Brian L.
我们使用小鼠模型研究了大麻素受体（CBr）激动剂Win 55，212-2（非选择性）和AM 1241（CBr 2选择性）以及外周受体（CBr 1）在癌诱导疼痛中的作用。通过局部注射人口腔鳞状细胞癌（SCC）在雌性小鼠的后爪中诱导肿瘤。SCC接种后4天开始出现明显疼痛，表现为机械刺激引起的退缩阈值降低，并持续至18天。局部施用Win 55、212-2（10 mg/kg）和AM 1241（10 mg/kg）显著提高了退缩阈值，表明抗伤害感受效应。同侧L5背根神经节中CBr 1蛋白的表达与同侧L4背根神经节和正常组织相比显著上调。这些发现支持大麻素能够在癌性疼痛中产生抗伤害感受的建议。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
We investigated the cannabinoid receptor (CBr) agonists Win55,212-2 (non-selective) and AM 1241 (CBr2 selective) and the peripheral receptor (CBr1) in carcinoma-induced pain using a mouse model. Tumors were induced in the hind paw of female mice by local injection of a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at 4 days after SCC inoculation and lasted to 18 days. Local administration of Win55,212-2 (10 mg/kg) and AM 1241 (10 mg/kg) significantly elevated withdrawal thresholds, indicating an antinociceptive effect. Ipsilateral expression of CBr1 protein in L5 DRG was significantly upregulated compared to ipsilateral L4 DRG and in normal tissue. These findings support the suggestion that cannabinoids are capable of producing antinociception in carcinoma-induced pain. (C) 2007 Elsevier Ireland Ltd. All rights reserved.