Development of physiological simulation environment for hemodynamics of cardiovascular system
Development of physiological simulation environment for hemodynamics of cardiovascular system
复制标题
心血管系统血流动力学生理模拟环境开发
DOI：
10.1109/apbme.2003.1302578
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
T. Kitamura
中科院分区：
文献类型：
--
作者：
K. Asami;T. Kitamura
本研究的目的是为心血管系统作为全身循环系统的一部分进行建模和诊断提供生理模拟环境。循环系统模型旨在根据临床测量定量地表示各种变化和疾病。对于某些测量或诊断水平，可以将循环系统建模为大小、分辨率或时间尺度的目标粒度。生理模拟的宏观模型和微观模型各有相反的优点和缺点。一方面，宏观模型包含全身各器官、功能和子系统的广泛生理信息，但不可能将随时间变化的变量细化为较小的时间单位。另一方面，微观模型只能分析单个子系统的微观行为，因为省略了整个身体的额外功能。因此，所提出的生理模拟方法集成了宏观循环和微观心血管系统模型，从而可以同时模拟长期宏观身体状况和短期微观血流。
The purpose of this study is to provide a physiological simulation environment for modeling and diagnosing the cardiovascular system as part of circulatory system in the whole body. The circulatory system model aims to represent various changes and diseases quantitatively based on clinical measurements. In respect with some measurement or diagnosis levels, the circulatory system could be modeled into a target granularity of sizes, resolutions, or timescales. There are opposite advantages and shortcomings in the macro and micro models for physiological simulation. On the one hand, the macro model contains a wide range of physiological information for various organs, functions, and subsystems within the whole body, but it is impossible to be detailed into small time units for time-dependent variables. On the other hand, the micro model enables to analyze microscopic behavior only for a single subsystem, because the extra functions of the whole body are omitted. Therefore, the proposed physiological simulation method integrates macro circulatory and micro cardiovascular system models, so that long-term macroscopic body conditions and short-term microscopic blood flow could be concurrently simulated.