Studies of the sex based variation of human growth hormone secretion.
Studies of the sex based variation of human growth hormone secretion.
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研究人类生长激素分泌的性别差异。
DOI：
10.1210/jcem-33-6-896
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
S. Fineberg
中科院分区：
文献类型：
--
作者：
T. Merimee;S. Fineberg
摘要为了阐明人类生长激素（HGH）分泌的性别差异的本质，进行了一项综合性研究，其中包括对两性和女性在月经周期中几种刺激后HGH分泌的详细调查。用适当的性激素进行预处理。在月经周期的每个时期都输注分级剂量的精氨酸。在高雌激素阶段的周期（排卵前阶段）的平均峰值人类生长激素的反应，以1/6克和1/12克精氨酸每磅体重显着大于在排卵期低雌激素阶段。精氨酸剂量较大（1/4 g/磅体重）时未出现类似变化。胰岛素诱导的血糖分级降低显示了类似的模式。当血糖浓度降至20 ~ 30 mg/100 ml时，HGH在排卵前升高至17.5 ± 5.0 μg/ml，排卵后升高至14.0 ± 4.2 μ g/ml，排卵后升高至14.0 ± 4.2 μg/ml。
ABSTRACT A comprehensive study was undertaken to clarify the nature of a sex-based variation of human growth hormone (HGH) secretion in man. This included a detailed investigation of HGH secretion after several stimuli in both sexes and in females during the menstrual cycle. Pretreatment with appropriate sex hormones was carried out. Graded doses of arginine were infused in each period of the menstrual cycle. During a high estrogen phase of the cycle (preovulatory phase) the mean peak human growth hormone response to 1/6 g and to 1/12 g of arginine per pound of body weight was significantly greater than during menstruation—a low estrogen phase. A similar variation did not occur with a greater dose (1/4 g per pound of body weight) of arginine. Graded decreases of plasma glucose induced by insulin revealed a similar pattern. With plasma glucose concentration decreasing between 20 and 30 mg/100 ml, HGH increased in the preovulatory phase to 17.5 ± 5.0 mμg/ml, in the postovulatory phase to 14.0 ± 4.2 mμg/ml, ...