Effect of resveratrol on the hyperexcitability of nociceptive neurons associated with ectopic hyperalgesia induced by experimental tooth movement
Effect of resveratrol on the hyperexcitability of nociceptive neurons associated with ectopic hyperalgesia induced by experimental tooth movement
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DOI：
10.1111/eos.12722
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发表时间：
2020-07-30
影响因子：
1.9
通讯作者：
Takeda, Mamoru
中科院分区：
文献类型：
--
作者：
Okubo, Nao;Ishikawa, Haruna;Takeda, Mamoru
本研究调查是否，在体内条件下，全身给药白藜芦醇减弱实验性牙齿运动引起的异位痛觉过敏与过度兴奋的伤害性三叉神经脊核尾侧（SpVc）神经元。从机械刺激施加到大鼠暴露于实验性牙齿移动的胡须垫逃脱的阈值显着低于对照组大鼠从第1天至第3天后的右上颌第一磨牙的运动。在白藜芦醇给药后第3天，暴露于实验性牙齿移动的大鼠中降低的机械阈值几乎恢复到假治疗的幼稚大鼠的水平。实验性牙齿移动后，SpVc神经元的平均伤害性机械阈值显着降低，但低阈值可以通过给药白藜芦醇逆转。在暴露于实验性牙齿移动的大鼠中观察到的伤害性机械刺激的伤害性SpVc神经元的较高放电频率在白藜芦醇给药后统计学上显著降低。这些结果表明，白藜芦醇通过抑制外周和/或中枢致敏来减弱实验性牙齿移动诱导的机械性异位痛敏。这些发现支持了白藜芦醇作为一种补充性替代药物，是一种潜在的预防实验性牙齿移动引起的异位痛觉过敏的治疗剂的观点。
The present study investigated whether, under in vivo conditions, systemic administration of resveratrol attenuates the experimental tooth movement-induced ectopic hyperalgesia associated with hyperexcitability of nociceptive trigeminal spinal nucleus caudalis (SpVc) neurons. The threshold of escape from mechanical stimulation applied to the ipsilateral whisker pad in rats exposed to experimental tooth movement was significantly lower than seen in control rats from day 1 to 3 following movement of the right maxillary first molar tooth. The lowered mechanical threshold in the rats exposed to experimental tooth movement had almost returned to the level of sham-treated naive rats at day 3 following administration of resveratrol. The mean mechanical threshold of nociceptive SpVc neurons was significantly lower after experimental tooth movement but the lower threshold could be reversed by administration of resveratrol. The higher discharge frequency of nociceptive SpVc neurons for noxious mechanical stimuli observed in rats exposed to experimental tooth movement was statistically significantly lower following resveratrol administration. These results suggest that resveratrol attenuates experimental tooth movement-induced mechanical ectopic hyperalgesia via suppression of peripheral and/or central sensitization. These findings support the idea that resveratrol, a complementary alternative medicine, is a potential therapeutic agent for the prevention of experimental tooth movement-induced ectopic hyperalgesia.