Triglyceride-glucose index in the development of peripheral artery disease: findings from the Atherosclerosis Risk in Communities (ARIC) Study.
Triglyceride-glucose index in the development of peripheral artery disease: findings from the Atherosclerosis Risk in Communities (ARIC) Study.
复制标题
甘油三酯-葡萄糖指数在外周动脉疾病发展中的作用：社区动脉粥样硬化风险 (ARIC) 研究的结果
DOI：
10.1186/s12933-021-01319-1
复制
发表时间：
2021-06-24
影响因子：
9.3
通讯作者：
Liu PM
中科院分区：
文献类型：
--
作者：
Gao JW;Hao QY;Gao M;Zhang K;Li XZ;Wang JF;Vuitton DA;Zhang SL;Liu PM
目前尚不清楚胰岛素抵抗的替代标志物--葡萄糖-葡萄糖（TyG）指数是否与外周动脉疾病（PAD）的发生具有前瞻性相关性。我们纳入了12，320名社区动脉粥样硬化风险研究参与者（年龄54.3 ± 5.7岁），基线时无PAD病史（访视1：1987-1989）。使用ln（空腹甘油三酯[mg/dL] ×空腹血糖[mg/dL]/2）确定TyG指数，并在1987年至2013年的5次访视时进行测量。PAD事件定义为首次因PAD诊断住院或随访期间测量的ABI < 0.90新发。我们分别使用考克斯回归和逻辑回归分析来量化TyG指数的基线和轨迹与PAD事件的相关性。在平均23年的随访中，1300名参与者发展为PAD。校正传统PAD风险因素后，TyG指数每增加1-SD（0.58），发生PAD的风险增加11.9%[风险比，1.119（95%CI，1.049-1.195）]。当个体按TyG指数四分位数分类时，结果相似[风险比，1.239（95%CI，1.028-1.492）;比较极端四分位数]。确定了沿着随访期间不同水平的稳定TyG指数的四种不同轨迹[低（22.2%）、中等（43.2%）、高（27.5%）和非常高（7.1%）轨迹组]。与TyG指数轨迹处于低水平的受试者相比，TyG指数轨迹处于高水平和非常高水平的受试者在对传统PAD风险因素进行多变量调整后，未来发生PAD的风险更大[比值比（95%CI）分别为1.404（1.132-1.740）和1.742（1.294-2.344）]。较高的TyG指数与PAD事件风险增加独立相关。TyG指数的长期轨迹有助于识别PAD风险较高的个体，这些个体需要采取特定的预防和治疗方法。试验注册：临床试验注册号：ARIC试验在clinicaltrials.gov注册为NCT 00005131。在线版本包含补充材料，可通过10.1186/s12933-021-01319-1获得。
It remains unclear whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, is prospectively associated with incident peripheral arterial disease (PAD). We included 12,320 Atherosclerosis Risk in Communities Study participants (aged 54.3 ± 5.7 years) free of a history of PAD at baseline (visit 1: 1987–1989). The TyG index was determined using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2), and measured at 5 visits between 1987 and 2013. Incident PAD was defined as the first hospitalization with PAD diagnosis or a new onset of measured ABI < 0.90 during follow-up visits. We quantified the association of both baseline and trajectories of TyG index with incident PAD using Cox regression and logistic regression analysis, respectively. Over a median follow-up of 23 years, 1300 participants developed PAD. After adjustment for traditional PAD risk factors, each 1-SD (0.58) increase in TyG index was associated with an 11.9% higher risk of incident PAD [hazard ratio, 1.119 (95% CI, 1.049–1.195)]. Results were similar when individuals were categorized by TyG index quartiles [hazard ratio, 1.239 (95% CI, 1.028–1.492); comparing extreme quartiles]. Four distinct trajectories of stable TyG indexes at various levels along the follow-up duration were identified [low (22.2%), moderate (43.2%), high (27.5%), and very high (7.1%) trajectory groups]. Compared with those with a TyG index trajectory at a low level, those participants with TyG index trajectories at high and very high levels had an even greater risk of future incident PAD [odds ratio (95%CI): 1.404 (1.132–1.740) and 1.742 (1.294–2.344), respectively] after multivariate adjustments for traditional PAD risk factors. Higher TyG index is independently associated with an increased risk of incident PAD. Long-term trajectories of TyG index help identify individuals at a higher risk of PAD who deserve specific preventive and therapeutic approaches. Trial registration: Clinical trial registration number: The ARIC trial was registered at clinicaltrials.gov as NCT00005131. The online version contains supplementary material available at 10.1186/s12933-021-01319-1.
登录
查看更多内容
DOI：
10.1161/hypertensionaha.113.01925
发表时间：
2014-02
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Garg PK;Biggs ML;Carnethon M;Ix JH;Criqui MH;Britton KA;Djoussé L;Sutton-Tyrrell K;Newman AB;Cushman M;Mukamal KJ
通讯作者：
Mukamal KJ
影响因子：
15.9
作者：
FERRANNINI, E;BARRETT, EJ;DEFRONZO, RA
通讯作者：
DEFRONZO, RA
影响因子：
168.9
作者：
Fowkes, F. Gerald R.;Rudan, Diana;Criqui, Michael H.
通讯作者：
Criqui, Michael H.
影响因子：
24
作者：
Gerhard-Herman, Marie D.;Gornik, Heather L.;Walsh, M. Eileen
通讯作者：
Walsh, M. Eileen
DOI：
10.1177/1358863x11436195
发表时间：
2012-04
期刊：
Vascular medicine (London, England)
影响因子：
--
作者：
Britton KA;Mukamal KJ;Ix JH;Siscovick DS;Newman AB;de Boer IH;Thacker EL;Biggs ML;Gaziano JM;Djoussé L
通讯作者：
Djoussé L