Contributions of Pavlovian incentive motivation to cue-potentiated feeding.
Contributions of Pavlovian incentive motivation to cue-potentiated feeding.
复制标题
巴甫洛夫激励动机对提示强化喂养的贡献。
DOI：
10.1038/s41598-018-21046-0
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发表时间：
2018
影响因子：
4.6
通讯作者：
Ostlund,SeanB
中科院分区：
文献类型：
--
作者：
Marshall,AndrewT;Halbout,Briac;Liu,AngelaT;Ostlund,SeanB
发出美味食物信号的信号会增强寻找食物和消耗食物的能力。本研究结合行为学、药理学和分析技术，探讨巴甫洛夫激励动机在线索强化喂养中的作用。我们发现，与蔗糖溶液(CS+)配对的线索可以转移其对摄食的控制，以刺激新容器处的蔗糖消耗，并且这种影响依赖于D1多巴胺受体的激活，已知的D1多巴胺受体调节其他形式的线索驱动的行为，但不调节味觉。对舔蔗糖行为的微观结构分析显示，CS+倾向于增加老鼠进行活跃舔食行为的频率，而不是对这些舔食行为的持续时间产生可靠的影响，而这一衡量标准与蔗糖的适口性有关。此外，我们发现CS+的个体差异引起的回合次数的增加与测试中的总蔗糖摄入量有关，支持了这一过程与有意义的进食行为失调有关的观点。因此，本研究(1)证明了多巴胺依赖的巴甫洛夫激励过程可以调节线索强化的摄食，(2)为分析这一方面的行为提供了一种实验和分析方法。
Cues signaling the availability of palatable food acquire the ability to potentiate food seeking and consumption. The current study employed a combination of behavioral, pharmacological, and analytical techniques to probe the role of Pavlovian incentive motivation in cue-potentiated feeding. We show that a cue paired with sucrose solution (CS+) can transfer its control over feeding to stimulate sucrose consumption at a new receptacle, and that this effect depends on activation of D1 dopamine receptors, which is known to modulate other forms of cue-motivated behavior but not taste palatability. Microstructural analyses of sucrose-licking behavior revealed that the CS+ tended to increase the frequency with which rats engaged in active bouts of licking behavior without having a reliable effect on the duration of those licking bouts, a measure that was instead associated with sucrose palatability. Furthermore, we found that individual differences in CS+ elicited increases in bout frequency were associated with total sucrose intake at test, supporting the view that this process was related to meaningful dysregulation of eating behavior. The current study, therefore, (1) demonstrates that a dopamine-dependent Pavlovian incentive motivational process can mediate cue-potentiated feeding, and (2) lays out an experimental and analytical approach for parsing this aspect of behavior.