Heat pain detection threshold is associated with the area of secondary hyperalgesia following brief thermal sensitization: a study of healthy male volunteers.
Heat pain detection threshold is associated with the area of secondary hyperalgesia following brief thermal sensitization: a study of healthy male volunteers.
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DOI：
10.2147/jpr.s121189
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发表时间：
2017
影响因子：
2.7
通讯作者：
Dahl JB
中科院分区：
文献类型：
--
作者：
Hansen MS;Wetterslev J;Pipper CB;Asghar MS;Dahl JB
皮肤短暂热致敏（BTS）和热痛检测阈值（HPDT）后继发性痛觉过敏的面积可能都具有关于疼痛敏感性和临床疼痛状态的预测能力。然而，HPDT与继发性痛觉过敏之间的关系仍未确定，生理特性的差异表明它们可能代表两种截然不同的疼痛实体。本研究的目的是探讨HPDT与bts诱导的继发性痛觉过敏之间的关系。121名健康男性参与者在2个独立的研究日接受了BTS（45°C， 3分钟）、HPDT和热刺激（45°C， 1分钟）疼痛的测试。单丝针刺刺激后继发性痛觉过敏的面积被量化。同时采用疼痛灾难化量表（PCS）和医院焦虑抑郁量表（HADS）。发现HPDT与继发性痛觉过敏面积的大小有显著相关性（p<0.0001）。由于HPDT升高1度，继发性痛觉过敏面积的预期变化估计为- 27.38 cm2, 95%置信区间（CI）为- 37.77至- 16.98 cm2， R2为0.19。同样，我们发现hads -抑郁亚评分与继发性痛觉过敏面积之间存在显著关联（p=0.046）， hads -抑郁亚评分每增加1分，继发性痛觉过敏的预期变化为11 cm2, 95% CI (0.19-21.82)， R2为0.03。我们发现继发性痛觉过敏区域与热刺激时PCS评分或疼痛之间无显著关联。HPDT与BTS后继发性痛觉过敏面积显著相关；然而，由于R2仅为19%，HPDT只能对BTS引起的继发性痛觉过敏区域大小的参与者间差异提供适度的解释。
The area of secondary hyperalgesia following brief thermal sensitization (BTS) of the skin and heat pain detection thresholds (HPDT) may both have predictive abilities in regards to pain sensitivity and clinical pain states. The association between HPDT and secondary hyperalgesia, however, remains unsettled, and the dissimilarities in physiologic properties suggest that they may represent 2 distinctively different pain entities. The aim of this study was to investigate the association between HPDT and BTS-induced secondary hyperalgesia. A sample of 121 healthy male participants was included and tested on 2 separate study days with BTS (45°C, 3 minutes), HPDT, and pain during thermal stimulation (45°C, 1 minute). Areas of secondary hyperalgesia were quantified after monofilament pinprick stimulation. The pain catastrophizing scale (PCS) and hospital anxiety and depression scale (HADS) were also applied. A significant association between HPDT and the size of the area of secondary hyperalgesia (p<0.0001) was found. The expected change in area of secondary hyperalgesia due to a 1-degree increase in HPDT was estimated to be −27.38 cm2, 95% confidence interval (CI) of −37.77 to −16.98 cm2, with an R2 of 0.19. Likewise, a significant association between HADS-depression subscore and area of secondary hyperalgesia (p=0.046) was found, with an estimated expected change in secondary hyperalgesia to a 1-point increase in HADS-depression subscore of 11 cm2, 95% CI (0.19–21.82), and with R2 of 0.03. We found no significant associations between secondary hyperalgesia area and PCS score or pain during thermal stimulation. HPDT and the area of secondary hyperalgesia after BTS are significantly associated; however, with an R2 of only 19%, HPDT only offers a modest explanation of the inter-participant variation in the size of the secondary hyperalgesia area elicited by BTS.