Detection of the CCR5-Δ32 HIV resistance gene in Bronze Age skeletons
Detection of the CCR5-Δ32 HIV resistance gene in Bronze Age skeletons
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DOI：
10.1038/sj.gene.6364172
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发表时间：
2005-06-01
影响因子：
5
通讯作者：
Oppermann, M
中科院分区：
文献类型：
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作者：
Hummel, S;Schmidt, D;Oppermann, M
趋化因子受体CCR 5基因（CCR 5-D32）的突变等位基因，赋予对HIV-1感染的抵抗力，被认为起源于历史上的单一突变事件，并由于未知的选择性优势在高加索人群中迅速扩大。在其他候选者中，鼠疫杆菌鼠疫耶尔森氏菌被认为是中世纪欧洲人口强大选择压力的潜在来源。在这里，我们报告扩增的CCR 5-D32 DNA序列从长达2900年的骨骼仍然从不同的埋葬地点在中部德国和南部意大利。此外，世纪吕贝克/北方德国鼠疫大流行的受害者中CCR 5-D32的等位基因频率与历史对照组没有差异。我们的研究结果表明，这种突变在史前欧洲人中已经很普遍。研究结果还反对鼠疫是导致这些人群中CCR 5-D32基因频率快速增加的主要选择力的可能性。
A mutant allele of the chemokine receptor CCR5 gene (CCR5-D32), which confers resistance to HIV-1 infection, is believed to have originated from a single mutation event in historic times, and rapidly expanded in Caucasian populations, owing to an unknown selective advantage. Among other candidates, the plague bacillus Yersinia pestis was implicated as a potential source of strong selective pressure on European populations during medieval times. Here, we report amplifications of the CCR5-D32 DNA sequence from up to 2900-year-old skeletal remains from different burial sites in central Germany and southern Italy. Furthermore, the allele frequency of CCR5-D32 in victims of the 14th century plague pandemic in Lubeck/ northern Germany was not different from a historic control group. Our findings indicate that this mutation was prevalent already among prehistoric Europeans. The results also argue against the possibility of plague representing a major selective force that caused rapid increase in CCR5-D32 gene frequencies within these populations.