A cluster of long non-coding RNAs exhibit diagnostic and prognostic values in renal cell carcinoma
A cluster of long non-coding RNAs exhibit diagnostic and prognostic values in renal cell carcinoma
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一组长非编码 RNA 在肾细胞癌中表现出诊断和预后价值
DOI：
10.18632/aging.102407
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发表时间：
2019-11-15
期刊：
影响因子：
5.2
通讯作者：
Zhang, Xiaoping
中科院分区：
文献类型：
--
作者：
Cheng, Gong;Liu, Di;Zhang, Xiaoping
在2018年美国估计的新癌症病例数量中，肾癌在男性和女性中都排在前10名。最近对肾透明细胞癌(CcRCC)患者进行了靶向治疗，但该疾病晚期患者的总体存活率并不像预期的那么好。因此，有必要发现有效的生物标志物用于早期诊断，并阐明ccRCC进展和转移的分子机制。越来越多的证据表明，长的非编码RNA(LncRNAs)在肿瘤的发展过程中发挥着重要作用。本研究共筛选出10个具有诊断和预后价值的候选LncRNAs：IGFL2-AS1、AC023043.1、AP000439.2、AC124854.1、AL355102.4、TMEM246-AS1、AL133467.3、ZNF582-AS1、LINC01510和PSMG3-AS1。富集分析揭示了代谢和功能途径，这可能与肾癌的发生密切相关。总结了糖酵解、氨基酸代谢、脂质合成、还原羧化、核苷酸代谢、跨膜转运和信号转导等六个具有代表性的过程。综上所述，本研究结果为肾细胞癌的预后和诊断提供了生物标志物，并可能为未来的靶向干预和分子治疗铺平道路。
Kidney cancer ranked in the top 10 for both men and women in the estimated numbers of new cancer cases in the United States in 2018. Targeted therapies have recently been administered to patients with clear cell renal cell carcinoma (ccRCC), but the overall survival of patients at the terminal stage of the disease has not been as good as expected. It is therefore necessary to uncover efficient biomarkers for early diagnosis, and to clarify the molecular mechanisms underlying ccRCC progression and metastasis. Increased evidence has shown that long non-coding RNAs (lncRNAs) play important roles during tumor progression. In this study, 10 candidate lncRNAs with diagnostic and prognostic values in ccRCC were identified: IGFL2-AS1, AC023043.1, AP000439.2, AC124854.1, AL355102.4, TMEM246-AS1, AL133467.3, ZNF582-AS1, LINC01510 and PSMG3-AS1. Enrichment analysis revealed metabolic and functional pathways, which may be closely associated with kidney cancer tumorigenesis. Six representative processes were summarized, namely glycolysis, amino acid metabolism, lipid synthesis, reductive carboxylation, nucleotide metabolism, transmembrane transport and signal transduction. In combination, the present results provided prognostic and diagnostic biomarkers for ccRCC and might pave the way for targeted intervention and molecular therapies in the future.