Lag-sensitive repetition suppression effects in the anterior parahippocampal gyrus
Lag-sensitive repetition suppression effects in the anterior parahippocampal gyrus
复制标题
DOI：
10.1002/hipo.20087
复制
发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Ranganath, C
中科院分区：
文献类型：
--
作者：
Brozinsky, CJ;Yonelinas, AP;Ranganath, C
对猴子的单单位记录研究表明，在刺激重复后，嗅周和内嗅皮层的神经元表现出活动减少，有些人认为这些重复抑制效应可能代表支持识别记忆的神经信号。重要的是，重复抑制效应在刺激重复之间的短时间间隔最明显。在这里，我们使用事件相关的功能磁共振成像（fMRI），以确定重复抑制效应在人类内侧颞叶，并确定这些影响是否是敏感的重复之间的间隔的长度。21名参与者进行了扫描，同时执行一个连续的识别记忆任务，其中项目重复之间的间隔参数变化从2到32个干预项目。我们在海马旁前回发现了重复抑制的证据，但只有当重复间隔相对较短时。此外，双侧海马区表现出滞后敏感的重复效应。我们的研究结果表明，在人类内侧颞叶皮层的活动，像猴子一样，表现出重复抑制效应，是敏感的重复之间的间隔的长度。((c)2005 Wiley-Liss，Inc.
Single-unit recording studies of monkeys have shown that neurons in perirhinal and entorhinal cortex exhibit activity reductions following stimulus repetition, and some have suggested that these iirepetition suppression effects may represent neural signals that support recognition memory. Critically, repetition suppression effects are most pronounced at short intervals between stimulus repetitions. Here, we used event-related functional magnetic resonance imaging (fMRI) to identify repetition suppression effects in the human medial temporal lobe and determine whether these effects are sensitive to the length of the interval between repetitions. Twenty-one participants were scanned while performing a continuous recognition memory task in which the interval between item repetitions was parametrically varied from 2 to 32 intervening items. We found evidence of repetition suppression in the anterior parahippocampal gyrus, but only when the repetition interval was relatively short. Moreover, bilateral hippocampal regions showed lag-sensitive repetition effects. Our results demonstrate that activity in the human medial temporal cortex, like that of monkeys, exhibits repetition suppression effects that are sensitive to the length of the interval between repetitions. ((c) 2005 Wiley-Liss, Inc.