Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
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DOI：
10.1128/jvi.72.1.164-169.1998
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发表时间：
1998-01-01
影响因子：
5.4
通讯作者：
Martin, MA
中科院分区：
文献类型：
--
作者：
Matano, T;Shibata, R;Martin, MA
静脉注射小鼠抗人CD8单抗(MAb)可导致外周血和淋巴组织中CD8(+)细胞的一过性耗竭。当在原始嵌合猿猴/人类免疫缺陷病毒感染期间给予CD8单抗时，会导致外周血和淋巴组织中的血浆和细胞相关病毒水平显著升高，并导致CD4细胞的长期耗竭。综上所述，这些结果直接证明CD8(+)T淋巴细胞积极参与控制灵长类慢病毒感染的急性期。
Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus macaques resulted in a transient depletion of CD8(+) cells in both the peripheral blood and lymphoid tissues. When administered during primary chimeric simian/human immunodeficiency virus infections, the CD8 MAb caused marked elevations of plasma and cell-associated virus levels in both the peripheral blood and lymphoid tissues and led to prolonged depletion of CD4 cells. Taken together, these results directly demonstrate that CD8(+) T lymphocytes are actively involved in controlling the acute phase of primate lentivirus infections.